000			03006cam a22004335i 4500
001			21734331
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006			m |o d |
007			cr |||||||||||
008			180803s2018 sz a||| b |||1 0|eng
010			_a 2019752041
020			_a9783319893532 (hbk)
040			_aDLC _beng _epn _erda _cDLC _dBD-DhUL
082	0	4	_a570 _bMOD
100	1		_aRoces, Maria Elena Alvarez-Buylla.
245	1	0	_aModeling methods for medical systems biology : _bregulatory dynamics underlying the emergence of disease processes / _cby María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez.
260			_aCham : _bSpringer, _c2018.
300			_axxi, 258 p. : _bill. (chiefly col.) ; _c24 cm.
365			_aEuro _b129.99
490	0		_aAdvances in experimental medicine and biology ; _v1069.
500			_aIncludes index.
504			_aBibliography: p. 215-240.
505	0		_aIntroduction -- Medical systems biology -- Modeling procedures -- Case of study -- Conclusions and Perspectives -- Bibliography.
520			_aThis book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.
588			_aDescription based on publisher-supplied MARC data.
650		0	_aBioinformatics.
650		0	_aMathematical models.
700	1		_aMartinez-Garcia, Juan Carlos. _ejt. aut.
700	1		_aDavila-Velderrain, Jose. _ejt. aut.
700	1		_aDominguez-Huttinger, Elisa. _ejt. aut.
700	1		_aMartínez-Sánchez, Mariana Esther. _ejt. aut.
776	0	8	_iPrint version: _tModeling methods for medical systems biology : regulatory dynamics underlying the emergence of disease processes _z9783319893532 _w(DLC) 2018938557
776	0	8	_iPrinted edition: _z9783030077488
776	0	8	_iPrinted edition: _z9783319893532
776	0	8	_iPrinted edition: _z9783319893556
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v1069
942			_2ddc _cBK
999			_c253249 _d253249