000			04907cam a2200505Ii 4500
001			ocn957589957
003			OCoLC
005			20190328114816.0
006			m o d
007			cr cnu|||unuuu
008			160901s2016 enk ob 001 0 eng d
040			_aN$T _beng _erda _epn _cN$T _dOPELS _dN$T _dEBLCP _dIDEBK _dOCLCF _dYDX _dOCLCO _dIDB _dOCLCO _dMERUC _dOCLCO _dOCLCQ _dOTZ _dUAB _dOCLCO _dMERER _dOCLCO _dOCLCQ _dOCLCO _dOCLCQ _dU3W _dOCLCO _dOCLCA _dOCLCQ _dOCLCO _dD6H _dOCLCO _dOCLCQ _dOCLCO _dOCLCQ _dAU@ _dOCLCO _dOCLCQ _dOCLCO _dOCLCQ _dOCLCA _dOCLCQ
019			_a961250225
020			_a9780128054031 _q(electronic bk.)
020			_a0128054034 _q(electronic bk.)
020			_z9780128054260 _q(print)
020			_z0128054263
035			_a(OCoLC)957589957 _z(OCoLC)961250225
050		4	_aRA1211
060	0	0	_a2016 J-286
060	1	0	_aQV 600
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.9 _223
100	1		_aGupta, P. K. _q(Pawan K.), _d1943- _eauthor.
245	1	0	_aFundamentals of toxicology : essential concepts and applications / _h[electronic resource] _cP.K. Gupta.
264		1	_aLondon, United Kingdom : _bAcademic Press is an imprint of Elsevier, _c2016.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
588	0		_aOnline resource; title from PDF title page (ScienceDirect, viewed September 12, 2016).
505	0		_aFront Cover; Fundamentals of Toxicology; Copyright Page; Contents; About the Author; Foreword; Preface; Unit I; 1 Introduction and historical background; 1.1 Introduction; 1.2 Historical Background; 1.2.1 Antiquity; 1.2.2 Middle Ages; 1.2.3 Age of Enlightenment; 1.3 Modern Toxicology; 1.3.1 After World War II; 2 Definitions and scope of toxicology; 2.1 Definitions; 2.2 Sub-disciplines of Toxicology; 2.3 Toxicant and Types of Toxicants; 2.4 Toxicity and Toxic Effects; 2.4.1 Toxicity in Relation to Frequency and Duration of Exposure.
505	8		_a2.4.2 Toxicity in Relation to Time of Development and Duration of Induced Effects2.5 Dose and Related Terms; 2.6 Other Common Terms; 2.7 Sources of Poisoning; 2.7.1 Accidental Poisoning; 2.7.2 Malicious Poisoning; 2.7.3 Occupational Exposure; 2.8 Duration and Frequency of Exposure; 3 Classification of poisons/toxicants; 3.1 Introduction; 3.2 Classification of Poisons; 3.3 Actions of Poisons; 4 Factors affecting toxicity; 4.1 Introduction; 4.2 Factors Affecting Toxicity; 4.2.1 Host Factors; 4.2.2 Factors Related to the Toxicant or Associated With Xenobiotics; 4.2.3 Environmental Conditions.
505	8		_a5 Natural laws concerning toxicology5.1 Introduction; 5.2 Tolerance; 5.3 Dose; 5.4 Time Action Curves; 5.5 Dose-Response Relationship; 5.5.1 Graded or Gradual Dose-Response Relationship; 5.5.2 Quantal or All-or-None Dose-Response Relationship; 5.6 Statistical Concept of Toxicity; 5.7 Variables of Dose-Response Curve; 5.8 Frequently Used Terms for Safety Evaluation of Drugs; 5.9 Interaction With Receptors; 5.10 Types of Xenobiotics; 5.11 Xenobiotic/Drug Interaction; 5.12 Nature and Extent of Toxicity Testing; 6 Hazard and risk assessment; 6.1 Introduction; 6.2 Risk Assessment Approach.
505	8		_a6.2.1 Preliminary Evaluation6.2.2 Toxicity Assessment; 6.2.3 Exposure Assessment; 6.3 Conclusion; Unit II; 7 Absorption, distribution, and excretion of toxicants; 7.1 Introduction; 7.2 Translocation of Xenobiotics Across Membranes; 7.2.1 Membrane Permeability; 7.2.2 Mechanism of Chemical Transfer; 7.2.3 Processes of Transport; 7.2.3.1 Passive transport; 7.2.3.2 Specialized active transport; 7.2.3.3 Additional transport processes; 7.3 Absorption; 7.3.1 Gastrointestinal Absorption; 7.3.2 Skin Absorption; 7.3.3 Lungs Absorption; 7.3.4 Parenteral Administration; 7.4 Distribution.
505	8		_a7.4.1 Tissue Permeability Barriers7.4.2 Transfer Across Other Membranes; 7.4.3 Factors Affecting Distribution and Tissue Retention; 7.4.4 Binding to Biological Macromolecules and Toxic Effects; 7.4.5 Redistribution; 7.5 Excretion; 7.5.1 Renal Excretion; 7.5.2 Biliary Excretion; 7.5.3 Gastrointestinal Tract; 7.5.4 Expired Air; 7.5.5 Sweat; 7.5.6 Saliva; 7.5.7 Milk; 7.5.8 Vaginal Secretions; 7.5.9 Other Routes; 8 Biotransformation; 8.1 Introduction; 8.2 Functions of Biotransformation; 8.3 Xenobiotic Metabolizing Enzymes; 8.4 Pathways of Biotransformation.
650		0	_aToxicology.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aToxicology. _2fast _0(OCoLC)fst01153364
650		2	_aToxicology.
655		4	_aElectronic books.
776	0	8	_iPrint version: _aGupta, P.K. (Pawan K.), 1943- _tFundamentals of toxicology. _dLondon, United Kingdom : Academic Press is an imprint of Elsevier, 2016 _z9780128054260 _z0128054263
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780128054260
999			_c247408 _d247408