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016 7 _a101664503
_2DNLM
019 _a908042071
_a1066453312
020 _a9780128014912
_q(electronic bk.)
020 _a0128014911
_q(electronic bk.)
020 _z9780128014110
020 _z0128014113
035 _a(OCoLC)905649781
_z(OCoLC)908042071
_z(OCoLC)1066453312
050 4 _aRM301.5
_b.T46 2015eb
060 0 0 _a2015 G-769
060 1 0 _aQV 38
072 7 _aMED
_x071000
_2bisacsh
082 0 4 _a615.7
_223
100 0 _aThorsteinn Loftsson,
_eauthor.
245 1 0 _aEssential pharmacokinetics : a primer for pharmaceutical scientists /
_h[electronic resource]
_cThorsteinn Loftsson.
264 1 _aAmsterdam ;
_aBoston :
_bElsevier Academic Press,
_c2015
264 4 _c�2015
300 _a1 online resource (vii, 170 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
520 _aEssential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.
504 _aIncludes bibliographical references and index.
588 0 _aPrint version record.
505 0 _aFront Cover; Essential Pharmacokinetics; Copyright Page; Contents; Preface; 1 Introduction; 1.1 Some Basic Concepts; 1.2 Pharmacokinetic Models; 1.3 Population Pharmacokinetics; References; 2 Basic Concepts of Pharmacokinetics; 2.1 One-Compartment Open Model; 2.1.1 IV Bolus Injection; 2.1.2 IV Infusion; 2.2 Two-Compartment Open Model; 2.2.1 IV Bolus Injection; 2.2.2 IV Infusion; 2.3 Three-Compartment Open Model; 2.4 Pharmacokinetics of Drug Absorption; 2.4.1 One-Compartment Open Model with Zero-Order Drug Absorption; 2.4.2 One-Compartment Open Model with First-Order Drug Absorption.
505 8 _a2.4.3 One-Compartment Open Model with Urine Sample Collection2.4.4 Two-Compartment Open Model with First-Order Drug Absorption; 2.4.5 Flip-Flop Pharmacokinetics; 2.5 Bioavailability; 2.6 Drug Distribution, Protein Binding, and Clearance; 2.6.1 Protein Binding; 2.6.2 Clearance; 2.7 Multiple-Dose Regimens; 2.7.1 Multiple-Dosage by IV Bolus Injection and One-Compartment Open Model; 2.7.2 Multiple-Dosage by Oral Administration and One-Compartment Open Model; 2.7.3 Loading Dose; 2.8 Nonlinear Pharmacokinetics; 2.8.1 Michaelis-Menten Equation; 2.9 Drug Metabolism.
505 8 _a2.10 Drug Permeation Through Biomembranes and Drug Transporters2.10.1 Biomembranes; 2.10.2 Passive Transport Through Mucosa; References; 3 Physicochemical Properties and Pharmacokinetics; 3.1 Lipinski's Rule of Five; 3.2 The Biopharmaceutics Classification System; 3.3 The Biopharmaceutics Drug Disposition Classification System; 3.4 Metabolizability, Soft Drugs, and Prodrugs; 3.5 Pharmacokinetics of Excipients; References; 4 Drug Pharmacokinetics After Alternative Routes of Administration; 4.1 Fentanyl Transdermal Patch; 4.2 Estradiol Sublingual Tablets; 4.3 Diazepam Suppositories.
505 8 _a4.4 Midazolam Nasal Spray4.5 Pulmonary Delivery (Inhalation) and Subcutaneous Injection of Insulin; 4.6 Topical Delivery of Dexamethasone to the Eye; References; 5 Pharmacologic Response and Drug Dosage Adjustments; 5.1 Therapeutic Drug Monitoring; 5.2 Dosage Adjustments; 5.3 Pharmacodynamics; 6 The Effect of Food and Excipients on Drug Pharmacokinetics; References; 7 Practice Problems; 7.1; 7.2; 7.3; 7.4; 7.5; 7.6; 7.7; 7.8; 7.9; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; References; Appendix I: Answers to Problems in Chapter 7; 7.1; A; B; C; D; E; F; G; 7.2; A; B; C; 7.3; A; B; C; 7.4.
505 8 _a7.57.6; A; B; 7.7; A; B; C; 7.8; A; B; C; 7.9; A; B; C; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; Appendix II: Symbols and Abbreviations; Index.
650 0 _aPharmacokinetics.
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 7 _aPharmacokinetics.
_2fast
_0(OCoLC)fst01060250
650 1 2 _aPharmacokinetics.
_0(DNLM)D010599
655 4 _aElectronic books.
655 0 _aElectronic book.
776 0 8 _iPrint version:
_aThorsteinn Loftsson.
_tEssential pharmacokinetics.
_dAmsterdam ; Boston : Elsevier Academic Press, �2015
_z9780128014110
856 4 0 _3ScienceDirect
_uhttp://www.sciencedirect.com/science/book/9780128014110
999 _c247061
_d247061