000			05043cam a2200601Ii 4500
001			ocn900781265
003			OCoLC
005			20190328114810.0
006			m o d
007			cr cnu|||unuuu
008			150127s2015 enk ob 001 0 eng d
010			_a 2015458943
040			_aN$T _beng _erda _epn _cN$T _dIDEBK _dN$T _dUIU _dOPELS _dE7B _dYDXCP _dOCLCF _dVLB _dABH _dOCLCQ _dWRM _dU3W _dCHVBK _dAU@ _dOCLCQ _dOCLCO _dWYU _dOCLCO _dOCLCA _dTKN _dCUY _dLOA _dZCU _dMERUC _dMERER _dICG _dK6U _dCOCUF _dOCLCQ _dVT2 _dDKC
016	7		_a101662180 _2DNLM
019			_a1066445834 _a1088979503
020			_a9780124051768 _q(electronic bk.)
020			_a0124051766 _q(electronic bk.)
020			_z9780124051706
020			_z0124051707
035			_a(OCoLC)900781265 _z(OCoLC)1066445834 _z(OCoLC)1088979503
050		4	_aRC512 _b.C55 2015eb
060	0	0	_a2015 F-907
060	1	0	_aWM 207
072		7	_aPSY _x022030 _2bisacsh
082	0	4	_a616.89 _223
245	0	0	_aClinical trial design challenges in mood disorders / _h[electronic resource] _cedited by Mauricio Tohen, Charles L. Bowden, Andrew A. Nierenberg, John R. Geddes.
264		1	_aLondon, UK : _bAcademic Press, _c[2015]
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
588	0		_aVendor-supplied metadata.
504			_aIncludes bibliographical references and index.
520			_aPoor clinical trial designs result in failed studies wasting hundreds of thousands of dollars in research funds. Poor clinical trial designs limit the rapid advancement of cures for disorders. Yet it's relatively easy to avoid classic poor designs via education about what constitutes good design and what the potential outcomes are for any shortcuts taken. The proposed book outlines the classic problems that researchers are faced with in designing clinical trials, whether its money, selection of subjects, regulatory issues etc, and how best to address them for the most definitive and generalizable results. This book is specific to clinical trial issues in psychiatric research, and comes from a task force in Bipolar Research. The contents herein were identified as the most major issues in psychiatric research. Authored by international contributors from academia, industry, regulatory agencies, and advocacy groups, this book summarizes problems in clinical design and the results of same, and whether and how the results can be applied into clinical practice.
505	0		_a<P>Preface</p> <p>Chapter 1: Clinical Trial Design of Maintenance Treatments in Bipolar Disorder Mauricio Tohen</p> <p>Chapter 2: Meta-Analysis of Clinical Trials in Bipolar Disorder John R. Geddes</p> <p>Chapter 3: Effectiveness Trials in Bipolar Disorders Andrew A. Nierenberg</p> <p>Chapter 4: Long-Term Treatment of Mood Disorders: Follow-Up of Acute Treatment Phase Studies Versus Continuation and Maintenance Phase Studies, and Enriched Versus Non-Enriched Designs Willem A. Nolen and Heinz Grunze</p> <p>Chapter 5: The Role of Noninferiority Designs in Bipolar Disorder Clinical Trials Edward Vieta and N�uria Cruz</p> <p>Chapter 6: The Use of Mixed Methods in Drug Discovery: Integrating Qualitative Methods into Clinical Trials Michael Berk, Rene�e Otmar, Olivia Dean, Lesley Berk and Erin Michalak</p> <p>Chapter 7: Sequential Multiple Assignment Randomized Treatment (SMART): Designs in Bipolar Disorder Clinical Trials Charles L. Bowden and Vivek Singh</p> <p>Chapter 8: Novel Study Designs for Clinical Trials in Mood Disorders Hong Jin Jeon and Maurizio Fava</p> <p>Chapter 9: Rating Scales in Bipolar Disorder Martha Sajatovic, Peijun Chen and Robert C. Young</p> <p>Chapter 10: Clinical Applicability of Results from Drug Trials in Bipolar Disorder -- An Attempt to Shed Light on a Complex Issue Rasmus Wentzer Licht</p> <p>Chapter 11: Clinical Trials in Developing Countries: Challenges in Design, Execution, and Regulation Chittaranjan Andrade and Tim Appaiah</p>
650		0	_aAffective disorders.
650		0	_aManic-depressive illness.
650		7	_aPSYCHOLOGY _xPsychopathology _xBipolar Disorder. _2bisacsh
650		7	_aAffective disorders. _2fast _0(OCoLC)fst00798861
650		7	_aManic-depressive illness. _2fast _0(OCoLC)fst01007706
650	1	2	_aBipolar Disorder _xtherapy. _0(DNLM)D001714Q000628
650	2	2	_aMood Disorders _xtherapy. _0(DNLM)D019964Q000628
650	2	2	_aClinical Trials as Topic. _0(DNLM)D002986
655		0	_aElectronic book.
655		4	_aElectronic books.
655		7	_aElectronic books. _2lcgft
700	1		_aTohen, Mauricio, _eeditor.
700	1		_aBowden, Charles L., _eeditor.
700	1		_aNierenberg, Andrew A. _q(Andrew Alan), _d1955- _eeditor.
700	1		_aGeddes, John R., _eeditor.
776	0	8	_iPrint version: _tClinical trial design challenges in mood disorders. _dLondon, England : Academic Press, c2015 _hxi, 179 pages _z9780124051706 _w2014946465
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780124051706
999			_c247039 _d247039