000			05143cam a2200505Ii 4500
001			ocn893128253
003			OCoLC
005			20190328114809.0
006			m o d
007			cr cnu---unuuu
008			141016t20142015ne o 000 0 eng d
040			_aN$T _beng _erda _epn _cN$T _dYDXCP _dUKMGB _dUIU _dOCLCF _dEBLCP _dOCLCQ _dDEBSZ _dOCLCQ _dU3W _dMERUC _dD6H _dOCLCQ _dWYU
016	7		_a016911996 _2Uk
016	7		_a016914121 _2Uk
019			_a893332896
020			_a9780123978905 _q(electronic bk.)
020			_a0123978904 _q(electronic bk.)
020			_z9780123978844
035			_a(OCoLC)893128253 _z(OCoLC)893332896
050		4	_aQH324.2
072		7	_aSCI _x007000 _2bisacsh
082	0	4	_a572.80285 _223
100	1		_aVodovotz, Yoram, _eauthor.
245	1	0	_aTranslational systems biology : concepts and practice for the future of biomedical research / _h[electronic resource] _cYoram Vodovotz, Gary An.
264		1	_aAmsterdam : _bAcademic Press, an imprint of Elsevier, _c[2014]
264		4	_c�2015
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed October 16, 2014).
505	0		_aFront Cover; Translational Systems Biology; Copyright Page; Dedication; Contents; Preface; Acknowledgments; I. Introduction and Overview; 1.1 Interesting Times: The Translational Dilemma and the Need for Translational Systems Biology of Inflammation; Primary Goal: Facilitate the Translation of Basic Biomedical Research to the Implementation of Effective Clinical Therapeut ... ; How to Approach This Book; References; II. The Current Landscape: Where It Came From, How We Got Here, and What Is Wrong.
505	8		_a2.1 A Brief History of the Philosophical Basis of the Scientific Endeavor: How We Know What We Know, and How to Know MoreModels in the Cave; Earth at the Center: A Reasonable Mistake, and an Unreasonable Perpetuation; The Scientific Method of Francis Bacon; Newton: The (Justifiable) Origins of Physics Envy; The Problem of Induction: Hume's Empiricism; Logic and Its True/False Promise: Logical Positivism, Godel and Popper; Charles Peirce Suggests Taking a Guess: The Abductive Approach; The Mapping Problem: Back to Plato?; Suggested Additional Readings.
505	8		_a2.2 A Brief History of Biomedical Research up to the Molecular Biology RevolutionReference; Suggested Additional Readings; 2.3 Biomedical Research Since the Molecular Revolution: An Embarrassment of Riches; References; 2.4 Randomized Clinical Trials: A Bridge Too Far?; References; 2.5 Complexity in Biomedical Research: Mysticism Versus Methods; References; Suggested Additional Readings; 2.6 Human Nature, Politics, and Translational Inertia; Setting the Table with Bacon; An Embarrassment of Riches; Shibboleths in Science: The Problem with Pedigrees.
505	8		_aIncentives and the Professionalization of ScienceDeep Pockets, with Holes: The Pharma Conundrum; Reference; III. Translational Systems Biology: How We Propose to Fix the Problems of the Current Biomedical Research Landscape; 3.1 Towards Translational Systems Biology of Inflammation; Primary Goal: Facilitate the Translation of Basic Biomedical Research to the Implementation of Effective Clinical Therapeut ... ; References; 3.2 Dynamic Knowledge Representation and the Power of Model Making; References.
505	8		_a3.3 A Roadmap for a Rational Future: A Systematic Path for the Design and Implementation of New TherapeuticsRational Evaluation of Drug Candidates: Knowing What Might Work, and More Importantly, What Won't; In silico Clinical Trials: Crossing the "Bridge Too Far"; From Populations to Individuals: Personalizing Medical Care; References; IV. Tools and Implementation of Translational Systems Biology: This is How We Do It; 4.1 From Data to Knowledge in Translational Systems Biology: An Overview of Computational Approaches Across the Scientific ...
520			_aAre we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the inte.
650		0	_aSystems biology.
650		7	_aSCIENCE _xLife Sciences _xBiochemistry. _2bisacsh
650		7	_aSystems biology. _2fast _0(OCoLC)fst01745552
655		4	_aElectronic books.
700	1		_aAn, Gary, _eauthor.
776	0	8	_iPrint version: _aVodovotz, Yoram. _tTranslational Systems Biology : Concepts and Practice for the Future of Biomedical Research. _dBurlington : Elsevier Science, �2014 _z9780123978844
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780123978844
999			_c246968 _d246968