000			05325cam a2200517Mi 4500
001			ocn891384880
003			OCoLC
005			20190328114809.0
006			m o d
007			cr cn|||||||||
008			140913t20152007enka ob 001 0 eng d
040			_aE7B _beng _erda _epn _cE7B _dOCLCO _dUIU _dCOO _dOPELS _dDEBSZ _dOCLCF _dOCLCQ _dYDX _dVGM _dU3W _dD6H _dCEF _dOCLCQ _dAU@ _dYDXCP _dWYU
019			_a892699551 _a1058329474
020			_a9780124059238 _q(e-book)
020			_a0124059236 _q(e-book)
020			_a0124059457
020			_a9780124059450
020			_z9780124059450
035			_a(OCoLC)891384880 _z(OCoLC)892699551 _z(OCoLC)1058329474
050		4	_aQH453 _b.P756 2015eb
082	0	4	_a571.85 _223
245	0	0	_aPrinciples of developmental genetics / _h[electronic resource] _cedited by Sally A. Moody.
250			_a2nd ed.
264		1	_aLondon, England : _bElsevier, _c2015.
264		4	_c�2007
264		4	_c�2015
300			_a1 online resource (773 pages) : _billustrations (some color)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references at the end of each chapters and index.
588	0		_aOnline resource; title from PDF title page (ebrary, viewed September 13, 2014).
505	0		_aFrontCover; Principles of Developmental Genetics; Copyright; Contents; Preface; Developmental Genetics: An Historical Perspective; RECOMMENDED RESOURCES; Contributors; Section I -- Emerging Technologiesand Systems Biology; Chapter 1 -- Generating Diversity and Specificity through Developmental Cell Signaling; SUMMARY; 1.1 INTRODUCTION; 1.2 IDENTIFICATION OF SIGNALING PATHWAY COMPONENTS; 1.3 FUNCTIONAL DIVERSIFICATION OF RELATED SIGNALING PROTEINS; 1.4 ROLES OF CYTOPLASMIC EXTENSIONS IN CELL SIGNALING; 1.5 FORMATION AND INTERPRETATION OF SIGNALING GRADIENTS.
505	8		_a1.6 TRANSCRIPTIONAL REGULATION BY DEVELOPMENTAL CELL SIGNALING PATHWAYS1.7 TRANSCRIPTION-INDEPENDENT RESPONSES TO CELL SIGNALING; 1.8 ROLES OF COMPUTATIONAL BIOLOGY IN DEVELOPMENTAL CELL SIGNALING STUDIES; 1.9 CLOSING REMARKS; 1.10 CLINICAL RELEVANCE: DEVELOPMENTAL CELL SIGNALING AND HUMAN DISEASE; ACKNOWLEDGMENTS; REFERENCES; Chapter 2 -- Applications of Deep Sequencing to Developmental Systems; SUMMARY; 2.1 INTRODUCTION; 2.2 USING RNA-SEQ TO MAP AND QUANTIFY TRANSCRIPTS; 2.3 CHROMATIN IMMUNOPRECIPITATION FOR IDENTIFYING PROTEIN-DNA INTERACTIONS.
505	8		_a2.4 DNASE I HYPERSENSITIVE SITE MAPPING TO IDENTIFY CIS-REGULATORY REGIONS2.5 INTERACTIONS AT A DISTANCE; 2.6 PROSPECTS; 2.7 CLINICAL RELEVANCE; RECOMMENDED RESOURCES; REFERENCES; Chapter 3 -- Using Mutagenesis in Mice for Developmental Gene Discovery; SUMMARY; 3.1 USE OF ENU AS A MUTAGEN; 3.2 ENU-INDUCED MUTATIONS IN MICE; 3.3 ENU-INDUCED MUTATIONS AFFECTING DEVELOPMENT; 3.4 IDENTIFICATION OF MODIFIER LOCI; 3.5 CLINICAL RELEVANCE; RECOMMENDED RESOURCES; REFERENCES; Chapter 4 -- Chemical Approaches to Controlling Cell Fate; SUMMARY; 4.1 INTRODUCTION.
505	8		_a4.2 CHEMICAL APPROACHES TO CONTROLLING CELL FATE4.3 CLINICAL RELEVANCE; ACKNOWLEDGMENT/GRANT SUPPORT; RECOMMENDED RESOURCES; Web sites; Reviews; REFERENCES; Chapter 5 -- BMP Signaling and Stem Cell Self-Renewal in the Drosophila Ovary; SUMMARY; 5.1 INTRODUCTION; 5.2 THE DROSOPHILA OVARY; 5.3 THE BMP SIGNALING PATHWAY; 5.4 REGULATION OF BMP SIGNALING BY EXTRINSIC FACTORS; 5.5 REGULATION OF BMP SIGNALING BY INTRINSIC FACTORS; 5.6 ADDITIONAL REGULATORS; 5.7 SELECTED TOPICS; 5.8 BMP SIGNALING AND STEM CELL HOMEOSTASIS IN VERTEBRATES; 5.9 CONCLUSIONS; 5.10 CLINICAL RELEVANCE; RECOMMENDED RESOURCES.
505	8		_aPublicationsWebsites; REFERENCES; Chapter 6 -- Genomic Analyses of Neural Stem Cells; SUMMARY; 6.1 INTRODUCTION; 6.2 THE IMPORTANCE OF GLOBAL ANALYSIS AND CAVEATS WHEN COMPARING CELL SAMPLES; 6.3 THE USE OF A REFERENCE STANDARD; 6.4 EPIGENETIC MODULATION; 6.5 MICRORNA; 6.6 MITOCHONDRIAL SEQUENCING; 6.7 TRANSCRIPTOME MAPPING; 6.8 DATA MINING: CHROMOSOME MAPPING, PATHWAY ANALYSIS, DATA REPRESENTATION; 6.9 GENERAL OBSERVATIONS ABOUT THE PROPERTIES OF NEURAL STEM CELLS; 6.10 SPECIES DIFFERENCES; 6.11 LACK OF A "STEMNESS" PHENOTYPE; 6.12 ALLELIC VARIABILITY; 6.13 AGE DEPENDENT CHANGES IN NSCS.
520			_aProviding expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries.
546			_aEnglish.
650		0	_aDevelopmental genetics.
650		7	_aDevelopmental genetics. _2fast _0(OCoLC)fst00891808
655		4	_aElectronic books.
655		0	_aElectronic books.
776	0	8	_iPrint version: _tPrinciples of developmental genetics. _dLondon, England : Elsevier, 2015, �2007 _hxxi, 749 pages _z9780124059450
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780124059450
999			_c246964 _d246964