000			06168cam a2200517Mi 4500
001			ocn889316833
003			OCoLC
005			20190328114808.0
006			m o d
007			cr cn|||||||||
008			140811t20142014caua ob 001 0 eng d
040			_aE7B _beng _erda _epn _cE7B _dOCLCO _dTEF _dN$T _dDEBSZ _dYDXCP _dOCLCQ _dOCLCF _dEMM _dOCLCQ _dOCLCO _dOCLCA _dWYU
019			_a1066655587
020			_a9780124055339 _q(electronic bk.)
020			_a0124055338 _q(electronic bk.)
020			_z9780124055285
020			_a0124055281
020			_a9780124055285
024	3		_a9780124055285
035			_a(OCoLC)889316833 _z(OCoLC)1066655587
050		4	_aQH603.L9 _b.A986 2014eb
072		7	_aSCI _x056000 _2bisacsh
082	0	4	_a571.655 _223
245	0	0	_aAutophagy : Volume 4 : Cancer, other pathologies, inflammation, immunity, infection, and aging / _h[electronic resource] _cedited by M.A. Hayat ; contributors Hagai Abeliovich [and thirty seven others].
264		1	_aSan Diego, California : _bAcademic Press, _c2014.
264		4	_c�2014
300			_a1 online resource (315 pages) : _billustrations
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0	0	_gChapter 1. _tIntroduction to Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging, volume 4 / _rM.A. Hayat -- _g1. _tGeneral applications. _gChapter 2. _tMolecular process and physiological significance of mitophagy / _rKe Wang, Daniel J. Klionsky -- _gChapter 3. _tPrinciples of mitophagy and beyond / _rAvia M. Tolkovsky, Kim Tieu -- _gChapter 4. _tQuality control in mitochondria / _rKobi J. Simpson-Lavy, Hagai Abeliovich -- _gChapter 5. _tMitophagy: an overview / _rDalibor Mijaljica, Mark Prescott, Rodney J. Devenish -- _g2. _tMolecular mechanisms. _gChapter 6. _tMitophagy induction and curcumin-mediated sonodynamic chemotherapy / _rChuanshan Xu, Wingnang Leung -- _gChapter 7. _tRole of nix in the maturation of erythroid cells through mitochondrial autotophagy / _rHuanhuan Sun [and others] -- _gChapter 8. _tRole of the antioxidant melatonin in regulating autophagy and mitophagy / _rJose A. Boga, Ana Coto-Montes, Russel J. Reiter -- _gChapter 9. _tUbiquitin ligase-assisted selective autophagy of mitochondria: determining its biological significance using drosophilia models / _rTsuyoshi Inoshita, Yuzuru Imai -- _gChapter 10. _tAtg32 confers selective mitochondrial sequestration as a cargo for autophagy / Yusuke Kurihara, Tomotake Kanki -- _gChapter 11. _tPARK2 induces autophagy removal of impaired mitochodria via ubiquitination / _rKah-Leong Lim [and others] -- _gChapter 12. _tUbiquination of mitofusins in PINK1/Parkin-mediated mitophagy / _rMatthew E. Gegg -- _gChapter 13. _tMitochondrial alterations in mitophagy in response to 6-hydroxydopamine / _rJoaqu�in Jord�an, Mar�ia E. Solesio, Mar�ia F. Galindo -- _g3. _tRole in disease. _gChapter 14. _tRole of mitochondrial fission and mitophagy in Parkinson's Disease / _rMar�ia F. Galindo, Mar�ia E. Solesio, Joaqu�in Jord�an -- _gChapter 15. _tMitophagy controlled by the PINK1-Parkin pathway is associated with Parkinson's Disease pathogenesis / _rYuzuru Imai, Nobutaka Hattori -- _gChapter 16. _tLoss of mitochondria during skeletal muscle atrophy / _rSudarsanreddy Lokireddy -- _gChapter 17. _tRole of impaired mitochondrial autophagy in cardiac aging / _rEmanuele Marzetti [and others].
588	0		_aOnline resource; title from PDF title page (ebrary, viewed August 9, 2014).
520	8		_aAnnotation _bAutophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagypresents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. . Brings together a wide swathe of experts (oncologists, neurosurgeons, physicians, research scientists, and pathologists) in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field . Discusses in detail myriad aspects of yeast mitophagy, including proteins involved, generation of reactive oxygen species (ROS), and various mechanisms of mitochondrial quality control. Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level . Organized for readers into easy-to-access sections: general applications; molecular mechanisms; and role in disease.
650		0	_aAutophagic vacuoles.
650	1	2	_aAutophagy. _0(DNLM)D001343
650	2	2	_aMitochondrial Degradation. _0(DNLM)D063306
650		7	_aSCIENCE _xLife Sciences _xAnatomy & Physiology. _2bisacsh
650		7	_aAutophagic vacuoles. _2fast _0(OCoLC)fst00824188
655		4	_aElectronic books.
655		0	_aElectronic book.
700	1		_aHayat, M. A., _d1940- _eeditor.
700	1		_aAbeliovich, Hagai, _econtributor.
776	0	8	_iPrint version: _tAutophagy : Volume 4. _dSan Diego, California : Academic Press, �2014 _hxxxvii, 274 pages _z9780124055285
856	4	0	_3ScienceDirect _uhttp://www.sciencedirect.com/science/book/9780124055285
999			_c246948 _d246948