000 04345cam a2200565Ii 4500
001 ocn903897512
003 OCoLC
005 20171025095303.0
006 m o d
007 cr cnu|||unuuu
008 150223s2015 gw ob 001 0 eng d
020 _a9783527678433
_q(electronic bk.)
020 _a3527678433
_q(electronic bk.)
020 _a1322949557
_q(ebk)
020 _a9781322949550
_q(ebk)
020 _a9783527678457
_q(electronic bk.)
020 _a352767845X
_q(electronic bk.)
024 7 _a10.1002/9783527678433
_2doi
028 0 1 _aEB00596207
_bRecorded Books
029 1 _aNZ1
_b15914892
029 1 _aDEBBG
_bBV043397534
035 _a(OCoLC)903897512
_z(OCoLC)903317911
_z(OCoLC)904961652
037 _a726237
_bMIL
040 _aDG1
_beng
_erda
_epn
_cDG1
_dIDEBK
_dCOO
_dCDX
_dOCLCF
_dRECBK
_dOCLCQ
_dDEBBG
_dEBLCP
049 _aMAIN
050 4 _aRS420
082 0 4 _a615.1/9
_223
245 0 0 _aSuccessful drug discovery /
_cedited by János Fischer and David P. Rotella.
_h[electronic resource]
264 1 _aWeinheim, Germany :
_bWiley-VCH,
_c2015.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aPart I: General Aspects. Serendipitous Target-Based Drug Discoveries / János Fischer, David P Rotella -- Drug Discoveries and Molecular Mechanism of Action / David C Swinney -- Part II: Drug Class. Insulin Analogs -- Improving the Therapy of Diabetes / John M Beals -- Part III: Case Histories. The Discovery of Stendra (Avanafil) for the Treatment of Erectile Dysfunction / Koichiro Yamada, Toshiaki Sakamoto, Kenji Omori, Kohei Kikkawa -- Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes / William N Washburn -- Elvitegravir, A New HIV-1 Integrase Inhibitor for Antiretroviral Therapy / Hisashi Shinkai -- Discovery of Linagliptin for the Treatment of Type 2 Diabetes Mellitus / Matthias Eckhardt, Thomas Klein, Herbert Nar, Sandra Thiemann -- The Discovery of Alimta (Pemetrexed) / Edward C Taylor -- Perampanel: A Novel, Noncompetitive AMPA Receptor Antagonist for the Treatment of Epilepsy / Shigeki Hibi -- Discovery and Development of Telaprevir (Incivek): A Protease Inhibitor to Treat Hepatitis C Infection / Bhisetti G Rao, Mark Murcko, Mark J Tebbe, Ann D Kwong -- Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1) / Sandhya Girish, Gail D Lewis Phillips, Fredric S Jacobson, Jagath R Junutula, Ellie Guardino.
520 _aThe first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds:small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting andlong-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of thedrug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs.
588 0 _aOnline resource; title from PDF title page (John Wiley, viewed February 23, 2015).
650 0 _aDrugs
_xDesign.
650 0 _aPharmaceutical chemistry.
650 4 _aMedical.
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 7 _aDrugs
_xDesign.
_2fast
_0(OCoLC)fst00898790
650 7 _aPharmaceutical chemistry.
_2fast
_0(OCoLC)fst01060115
655 4 _aElectronic books.
700 1 _aFischer, János,
_eeditor.
700 1 _aRotella, David P.,
_eeditor.
776 0 8 _iPrint version:
_z9783527678433
_w(OCoLC)903897512
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527678433
_zWiley Online Library
942 _2ddc
_cBK
999 _c207893
_d207893