000			04669cam a2200625 i 4500
001			ocn900159220
003			OCoLC
005			20171025130400.0
006			m o d
007			cr |||||||||||
008			150112s2015 nju ob 001 0 eng
010			_a 2015001033
020			_a9781118772386 (ePub)
020			_a1118772385 (ePub)
020			_a9781118772294 (Adobe PDF)
020			_a1118772296 (Adobe PDF)
020			_z9781118772324 (cloth)
020			_a9781118772287
020			_a1118772288
029	1		_aNZ1 _b16093624
029	1		_aCHVBK _b338063897
029	1		_aCHBIS _b010485596
029	1		_aGBVCP _b829867864
029	1		_aDEBBG _bBV042991566
029	1		_aDEBBG _bBV043397442
035			_a(OCoLC)900159220 _z(OCoLC)912320591
040			_aDLC _beng _erda _cDLC _dN$T _dIDEBK _dDG1 _dE7B _dCDX _dYDXCP _dCHVBK _dCOO _dEBLCP _dDEBBG _dOCLCQ _dRECBK _dCCO
042			_apcc
049			_aMAIN
050	0	0	_aQP552.M47
060	1	0	_aQU 136
072		7	_aSCI _x007000 _2bisacsh
082	0	0	_a572/.696 _223
245	0	0	_aMatrix metalloproteinase biology / _cedited by Irit Sagi and Jean P. Gaffney. _h[electronic resource]
264		1	_aHoboken, NJ : _bWiley Blackwell, _c[2015]
300			_a1 online resource.
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aMatrix metalloproteinases : from structure to function / Maciej J. Stawikowski and Gregg B. Fields -- Dynamics and mechanisms of substrate recognition by matrix metalloproteinases / Ivan E. Collier and Gregory Goldberg -- Matrix metalloproteinases : structure and dynamics in substrates recognition and processing / Marco Fragai, Claudio Luchinat -- Metzincin modulators : beyond the active site / Dmitriy Minond -- Therapeutics targeting matrix metalloproteinases / Jillian Cathcard, Ashleigh Pulkoski-Gross, Stanley Zucker, and Jian Cao -- Matrix metalloproteinases : modification of extracellular matrix-medicated signaling / Howard C. Crawford and M. Sharon Stack -- Meprin and Adam metalloproteinases : two sides of the same coin? / Christopher Becker-Pauly and Stefan Rose-John -- Metalloproteinases in innate immunity and disease / Antoine Dufour and Christopher Overall -- MMPS : from genomics to degradomics / Barbara Grünwald, Pascal Schlage, Achim Krüger, and Ulrich auf dem Keller -- Biology and clinical significance of MMPS / Di Jia, Roopali Roy, and Marsha A. Moses.
520			_aDiscussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs. The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases. The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics. The following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states. Written and edited by leaders in the field, Matrix Metalloproteinase Biology addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.
650		0	_aMetalloproteinases.
650		0	_aExtracellular matrix proteins.
650		0	_aMatrix Metalloproteinases.
650		7	_aSCIENCE / Life Sciences / Biochemistry _2bisacsh
650		2	_aMatrix Metalloproteinases.
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aSagi, Irit, _eeditor.
700	1		_aGaffney, Jean, _eeditor.
776	0	8	_iPrint version: _tMatrix metalloproteinase biology _dHoboken, NJ : John Wiley & Sons Inc., [2015] _z9781118772324 _w(DLC) 2015000037
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118772287 _zWiley Online Library
942			_2ddc _cBK
999			_c207835 _d207835