| 000 | 04702cam a2200697 a 4500 | ||
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| 001 | ocn785722063 | ||
| 003 | OCoLC | ||
| 005 | 20171114105345.0 | ||
| 006 | m o d | ||
| 007 | cr un|---uuuuu | ||
| 008 | 120411s2012 enk ob 001 0 eng | ||
| 010 | _a 2012015088 | ||
| 020 |
_a9781118348994 _q(ePub) |
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| 020 |
_a1118348990 _q(ePub) |
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| 020 |
_a9781118348963 _q(Adobe PDF) |
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| 020 |
_a1118348966 _q(Adobe PDF) |
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| 020 |
_a9781118348987 _q(MobiPocket) |
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| 020 |
_a1118348982 _q(MobiPocket) |
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| 020 |
_a9781118348970 _q(electronic bk.) |
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| 020 |
_a1118348974 _q(electronic bk.) |
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| 020 |
_z9781119995951 _q(cloth) |
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| 020 |
_z1119995957 _q(cloth) |
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| 020 |
_z9781119995944 _q(pbk.) |
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| 020 |
_z1119995949 _q(pbk.) |
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| 029 | 1 |
_aAU@ _b000049032391 |
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| 029 | 1 |
_aDEBBG _bBV042795159 |
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_aDEBSZ _b397319665 |
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_aDEBSZ _b425885321 |
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_aNZ1 _b15916053 |
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| 029 | 1 |
_aAU@ _b000059227966 |
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| 035 |
_a(OCoLC)785722063 _z(OCoLC)811865406 _z(OCoLC)844915169 |
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| 040 |
_aDLC _beng _epn _cDLC _dYDX _dEBLCP _dN$T _dUIU _dMERUC _dDG1 _dYDXCP _dE7B _dUBY _dUWO _dCDX _dDEBSZ _dIUL _dOCLCF _dCOO _dOCLCQ |
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| 042 | _apcc | ||
| 049 | _aMAIN | ||
| 050 | 0 | 0 | _aQP601 |
| 072 | 7 |
_aMED _x008000 _2bisacsh |
|
| 082 | 0 | 0 |
_a612/.0151 _223 |
| 100 | 1 | _aBugg, Tim. | |
| 245 | 1 | 0 |
_aIntroduction to enzyme and coenzyme chemistry / _cT.D.H. Bugg. _h[electronic resource] |
| 250 | _a3rd ed. | ||
| 260 |
_aChichester, West Sussex : _bWiley, _c2012. |
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| 300 | _a1 online resource. | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 8 | _a2.6 The folded tertiary structure of proteins2.7 Enzyme structure and function; 2.8 Metallo-enzymes; 2.9 Membrane-associated enzymes; 2.10 Glycoproteins; 3 Enzymes Are Wonderful Catalysts; 3.1 Introduction; 3.2 A thermodynamic model of catalysis; 3.3 Proximity effects; 3.4 The importance of transition state stabilisation; 3.5 Acid/base catalysis in enzymatic reactions; 3.6 Nucleophilic catalysis in enzymatic reactions; 3.7 The use of strain energy in enzyme catalysis; 3.8 Desolvation of substrate and active site nucleophiles; 3.9 Catalytic perfection. | |
| 505 | 8 | _a3.10 The involvement of protein dynamics in enzyme catalysis4 Methods for Studying Enzymatic Reactions; 4.1 Introduction; 4.2 Enzyme purification; 4.3 Enzyme kinetics; 4.4 The stereochemical course of an enzymatic reaction; 4.5 The existence of intermediates in enzymatic reactions; Direct observation; Trapping; Chemical inference; Isotope exchange; 4.6 Analysis of transition states in enzymatic reactions; 4.7 Determination of active site catalytic groups; 5 Hydrolytic and Group Transfer Enzymes; 5.1 Introduction; 5.2 The peptidases; The Serine Proteases; The Cysteine Proteases. | |
| 505 | 8 | _aThe Metallo-proteasesThe Aspartyl Proteases; CASE STUDY: HIV-1 protease; 5.3 Esterases and lipases; 5.4 Acyl transfer reactions in biosynthesis (coenzyme A); 5.5 Enzymatic phosphoryl transfer reactions; 5.6 Adenosine 5'-triphosphate (ATP); 5.7 Enzymatic glycosyl transfer reactions; 5.8 Methyl group transfer: use of S-adenosyl methionine and tetrahydrofolate coenzymes for one-carbon transfers; 6 Enzymatic Redox Chemistry; 6.1 Introduction; 6.2 Nicotinamide adenine dinucleotide-dependent dehydrogenases; 6.3 Flavin-dependent dehydrogenases and oxidases; 6.4 Flavin-dependent mono-oxygenases. | |
| 520 | _aLooking at enzymes from an organic chemistry perspective, this updated reference includes information on recent advances in our understanding of enzyme action; topical examples to illustrate key points; two-color figures of the active sites of enzymes discussed in the text to illustrate the interplay between enzyme structure and function; and end-of-chapter problems to allow readers to check their understanding of the material. This concise but comprehensive guide is essential for undergraduate and postgraduate students of organic, bio-organic, and medicinal chemistry, chemical biology, bioche. | ||
| 588 | 0 | _aPrint version record and CIP data provided by publisher. | |
| 650 | 0 | _aEnzymes. | |
| 650 | 0 | _aCoenzymes. | |
| 650 | 7 |
_aMEDICAL _xBiochemistry. _2bisacsh |
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| 650 | 7 |
_aCoenzymes. _2fast _0(OCoLC)fst00866295 |
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| 650 | 7 |
_aEnzymes. _2fast _0(OCoLC)fst00913605 |
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| 655 | 4 | _aElectronic books. | |
| 776 | 0 | 8 |
_iPrint version: _aBugg, Tim. _tIntroduction to enzyme and coenzyme chemistry. _b3rd ed. _dHoboken, NJ : Wiley, 2012 _z9781119995951 _w(DLC) 2012008853 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118348970 _zWiley Online Library |
| 942 |
_2ddc _cBK |
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| 999 |
_c205811 _d205811 |
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