000 05227cam a2200721 a 4500
001 ocn785558885
003 OCoLC
005 20171115081431.0
006 m o d
007 cr |||||||||||
008 120410s2012 enk ob 001 0 eng
010 _a 2012014806
020 _a9781118307878
_q(ePub)
020 _a1118307879
_q(ePub)
020 _a9780470711408
_q(Adobe PDF)
020 _a047071140X
_q(Adobe PDF)
020 _a9781118307885
_q(MobiPocket)
020 _a1118307887
_q(MobiPocket)
020 _a9780470711415
_q(electronic bk.)
020 _a0470711418
_q(electronic bk.)
020 _z9780470711187
_q(hardback)
020 _z0470711183
_q(hardback)
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029 1 _aDKDLA
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029 1 _aGBVCP
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029 1 _aNZ1
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035 _a(OCoLC)785558885
040 _aDLC
_beng
_epn
_cDLC
_dYDX
_dEBLCP
_dMERUC
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042 _apcc
049 _aMAIN
050 0 0 _aTP156.M65
072 7 _aMED
_x023000
_2bisacsh
072 7 _aMED
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082 0 0 _a615.1/9
_223
084 _aSCI013040
_2bisacsh
245 0 0 _aHot-melt extrusion : pharmaceutical applications /
_cedited by Dionysios Douroumis.
_h[electronic resource]
260 _aChichester, West Sussex, UK :
_bWiley,
_c2012.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 0 _aAdvances in phamaceutical technology
504 _aIncludes bibliographical references and index.
505 0 _aHot-melt Extrusion:Pharmaceutical Applications; Contents; List of Contributors; Preface; 1. Single-screw Extrusion: Principles; 1.1 Introduction; 1.2 Ideal Compounding; 1.3 Basics of the Single-screw Extruder; 1.3.1 Screw Feed Section; 1.3.2 Screw Compressor Section; 1.3.3 Screw Metering Section; 1.3.4 Mixers; 1.3.5 Limitations of Conventional Single-screw Mixers; 1.4 SSE Elongational Mixers; 1.5 Summary; References; 2. Twin-screw Extruders for Pharmaceutical Hot-melt Extrusion: Technology, Techniques and Practices; 2.1 Introduction; 2.2 Extruder Types and Working Principle.
520 _a"Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science"--
_cProvided by publisher.
520 _a"First book related to the use of hot melt extrusion for pharmaceutical applications"--
_cProvided by publisher.
588 0 _aPrint version record and CIP data provided by publisher.
650 0 _aMolding (Chemical technology)
650 0 _aDrugs
_xExtrusion.
650 0 _aPharmaceutical chemistry.
650 0 _aDrug delivery systems.
650 7 _aSCIENCE
_xChemistry
_xOrganic.
_2bisacsh
655 4 _aElectronic books.
655 7 _aElectronic books.
_2local
700 1 _aDouroumis, Dennis.
776 0 8 _iPrint version:
_tHot-melt extrusion.
_dHoboken : Wiley, 2012
_z9780470711187
_w(DLC) 2012005814
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9780470711415
_zWiley Online Library
942 _2ddc
_cBK
999 _c205808
_d205808