000			04338cam a2200685Ka 4500
001			ocn729724693
003			OCoLC
005			20171119081024.0
006			m o d
007			cr cn|||||||||
008			110609s2011 gw a ob 001 0 eng d
020			_a9783527633470 _q(electronic bk.)
020			_a3527633472 _q(electronic bk.)
020			_a9783527633487 _q(electronic bk.)
020			_a3527633480 _q(electronic bk.)
020			_a1283283247
020			_a9781283283243
020			_z9783527317905
020			_z3527317902
024	8		_a9786613283245
029	1		_aAU@ _b000049641601
029	1		_aGBVCP _b790033518
029	1		_aNZ1 _b15916500
029	1		_aDEBBG _bBV043393179
035			_a(OCoLC)729724693 _z(OCoLC)756898492 _z(OCoLC)757403635 _z(OCoLC)759006763 _z(OCoLC)816865413
037			_a10.1002/9783527633470 _bWiley InterScience _nhttp://www3.interscience.wiley.com
040			_aDG1 _beng _epn _cDG1 _dYDXCP _dN$T _dCDX _dOCLCQ _dOCLCO _dOCLCQ _dUWO _dOCLCQ _dOCLCA _dNLGGC _dIDEBK _dOCLCQ _dDEBBG
049			_aMAIN
050		4	_aRM666.E548 _bP76 2011
060		4	_aW1 _bME9613H v.49 2011
060		4	_aQU 143
072		7	_aMED _x071000 _2bisacsh
072		7	_aTDCW _2bicssc
082	0	4	_a615.798 _222
245	0	0	_aProtein kinases as drug targets / _cedited by Bert Klebl, Gerhard Müller, and Michael Hamacher. _h[electronic resource]
260			_aWeinheim : _bWiley-VCH ; _aChichester : _bJohn Wiley [distributor], _c©2011.
300			_a1 online resource (xxi, 373 pages) : _billustrations (some color).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aMethods and principles in medicinal chemistry ; _v49
504			_aIncludes bibliographical references and index.
505	0		_aIn vitro characterization of small-molecule kinase inhibitors -- Screening for kinase inhibitors: from biochemical to cellular assays -- Dissecting phosphorylation networks: the use of analogue-sensitive kinases and more specific kinase inhibitors as tools -- Rational drug design of kinase inhibitors for signal transduction therapy -- Kinaes inhibitors in signal transduction therapy -- Design principles of deep pocket-targeting protein kinase inhibitors -- From discovery to clinic: aurora kinase inhibitors as novel treatments for cancer -- Discovery and design of protein kinase inhibitors: targeting the cell cycle in oncology -- Medicinal chemistry approaches for the inhibition of the p38 MAPK pathway -- Cellular protein kinases as antiviral targets -- Prospects for TB therapeutics targeting mycobacterium tuberculosis phosphosignaling networks.
520			_aWith Kinase inhibitors being widely seen as the long-sought 'magic bullet' to conquer cancer, this fully comprehensive guide to kinase inhibitor drug development covers the entire drug pipeline from target identification to compound development and clinical application. Volume 1 focuses upon the medicinal chemistry of kinase drugs, from target identification to lead optimization, and contains numerous contributions from large and small pharmaceutical companies. Volume 2 surveys current and future therapeutic application areas for kinase inhibitor drugs, with a strong focus on oncology drugs, as this is the most important therapeutic field for these drugs. In addition, all six currently approved kinase inhibitor drugs (small molecules and antibodies) are described, and their performances in clinical practice are discussed.
588	0		_aPrint version record.
650		0	_aProtein kinases _xInhibitors.
650		0	_aAntineoplastic agents _xDevelopment.
650		2	_aProtein Kinase Inhibitors _xtherapeutic use.
650		2	_aDrug Delivery Systems.
650		2	_aDrug Discovery.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
655		4	_aElectronic books.
700	1		_aMüller, Gerhard.
700	1		_aKlebl, Bert.
710	2		_aWiley InterScience (Online service)
776	0	8	_iPrint version: _tProtein kinases as drug targets. _dWeinheim : Wiley-VCH ; Chichester : John Wiley [distributor], ©2011 _z9783527317905 _w(OCoLC)664325820
830		0	_aMethods and principles in medicinal chemistry ; _v49.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527633470 _zWiley Online Library
942			_2ddc _cBK
999			_c205092 _d205092