TY - BOOK AU - Rankovic, Zoran. AU - Morphy, Richard. TI - Lead generation approaches in drug discovery SN - 9780470257 AV - RM301.25 .L433 2010 U1 - 615.19 22 PY - 2010/// CY - Hoboken, N.J. PB - John Wiley KW - Drug development KW - Drugs KW - Design KW - High throughput screening (Drug development) KW - Drug Discovery KW - methods N1 - Includes bibliographical references and index; Lead discovery : the process / William F. Michne -- High throughput screening approach to lead discovery / Zoran Rankovic, Craig Jamieson, and Richard Morphy -- In silico screening / Dagmar Stumpfe, Hanna Geppert, and Jürgen Bajorath -- Fragment-based lead discovery / Jeffrey S. Albert -- Design of multitarget ligands / Richard Morphy and Zoran Rankovic -- De novo drug design / Gisbert Schneider, Markus Hartenfeller, Ewgenij Proschak -- Role of natural products in drug discovery / Hugo Lachance, Stefan Wetzel, and Herbert Waldmann -- Early screening for ADMET properties / Dennis A. Smith -- Role of chemistry in lead discovery / Roland E. Dolle and Karin Worm ER -