04563cam a2200361 a 45000010008000000030008000080050017000160080041000330100017000740200015000910350020001060350023001260350017001490400030001660500021001960820016002172450096002332460038003292500012003672600059003793000035004383650017004735040053004905051002005435050970015455051011025155050541035266500030040676500031040977000021041287000031041497000021041803387298BD-DhUL20150121171945.0010921s2002    paua     b    001 0 eng    a  2001050327  a0683307371  a(OCoLC)48057043  a(OCoLC)ocm48057043  a(NNC)3387298  aBD-DhULcBD-DhULdOrLoB-B00aRS403b.P75 200200a615.19bWIF00aFoye's principles of medicinal chemistry /c[edited by] David A. Williams, Thomas L. Lemke.30aPrinciples of medicinal chemistry  a5th ed.  aPhiladelphia :bLippincott Williams & Wilkins,cc2002.  axii, 1114 p. :bill. ;c29 cm.  aIRSb1500.00  aIncludes bibliographical references and indexes.00tIntroduction: Origins of Medicinal Chemistry /rWilliam O. Foye --gPt. I.tPrinciples of Drug Discovery --tOverview: Drug Design and Development: A Perspective /rMichael Williams.g1.tNatural Products /rAlice M. Clark.g2.tDrug Design and Relationship of Functional Groups to Pharmacologic Activity /rJames J. Knittel and Robin M. Zavod.g3.tMolecular Modeling and Drug Design /rEric Billings.g4.tReceptors and Drug Action /rTimothy J. Maher and David A. Johnson.g5.tDrug Design Through Enzyme Inhibition /rStephen G. Kerr.g6.tPeptide and Protein Drugs /rMichael Mokotoff.g7.tPhysicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics /rSunil Jambhekar.g8.tDrug Metabolism /rDavid A. Williams.g9.tU.S. Drug Regulation: An Overview /rDouglas J. Pisano --gPt. II.tPharmacodynamic Agents --tOverview: Drug Receptors: A Perspective /rDavid J. Triggle.g10.tDrugs Affecting Cholinergic Neurotransmission /rDanny L. Lattin and E. Kim Fifer.80g11.tDrugs Affecting Adrenergic Neurotransmission /rRobert Griffith.g12.tSerotonin Receptors and Drugs Affecting Serotonergic Neurotransmission /rRichard A. Glennon and Malgorzata Dukat.g13.tLocal Anesthetics /rMatthias C. Lu.g14.tVolatile Anesthetics /rTimothy J. Maher.g15.tHypnotics /rWilliam Soine.g16.tAntiseizure Drugs /rBarbara W. Leduc.g17.tPsychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents /rRaymond G. Booth and John L. Neumeyer.g18.tHallucinogens, Stimulants, and Related Drugs of Abuse /rRichard A. Glennon.g19.tOpioid Analgesics /rDavid S. Fries.g20.tDrugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents /rRaymond G. Booth and John L. Neumeyer.g21.tCardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs /rAhmed S. Mehanna.g22.tDiuretics /rGary O. Rankin.g23.tAngiotensin Converting Enzyme Inhibitors, Antagonists and Calcium Blockers /rMarc W. Harrold.80g24.tCentral and Peripheral Sympatholytics and Vasodilators /rDavid A. Williams.g25.tAntihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis /rMarc W. Harrold.g26.tAntithrombotics, Thrombolytics, Coagulants and Plasma Extenders /rRobert B. Palmer.g27.tInsulin and Oral Hypoglycemic Drugs /rRobert A. Wiley.g28.tAdrenocorticoids /rDuane D. Miller, Robert W. Brueggemeier and James T. Dalton.g29.tEstrogen, Progestins and Androgens /rRobert W. Brueggemeier, Duane D. Miller and James T. Dalton.g30.tThyroid Function and Thyroid Drugs /rAli R. Banijamali.g31.tCalcium Homeostasis /rRobin M. Zavod.g32.tNonsteroidal Anti-Inflammatory Agents /rRonald F. Borne.g33.tAntihistamines and Related Antiallergic and Antiulcer Agents /rWendel L. Nelson.g34.tAntibiotics and Antimicrobial Agents /rLester A. Mitscher.g35.tAntiparasitic Agents /rThomas L. Lemke.g36.tAntifungal Drugs /rRobert Griffith and Timothy Tracy.g37.tAntimycobacterial Agents /rThomas L. Lemke.80g38.tCancer and Cancer Chemotherapy /rPatrick S. Callery and Peter M. Gannett.g39.tAntiviral Agents and Protease Inhibitors /rManohar L. Sethi --gPt. III.tRecent Advances in Drug Discovery.g40.tPharmaceutical Biotechnology /rRobert D. Sindelar.g41.tGene Therapy /rRonald E. Reid.g42.tAntisense Therapeutic Agents /rMarilyn K. Speedie.g43.tSelective Estrogen Receptor Modulators /rV. Craig Jordan --tpKa Values for Some Drugs and Miscellaneous Organic Acids and Bases; pH Values for Tissue Fluids /rDavid A. Williams. 0aPharmaceutical chemistry. 2aChemistry, Pharmaceutical.1 aLemke, Thomas L.1 aWilliams, David A.,d1938-1 aFoye, William O.