02346cam a22004338a 4500 16780199 BD-DhUL 20150120190900.0 110512s2012 nyu b 001 0 eng 2011020446 9780071603935 (hardcover : alk. paper) 007160393X (hardcover : alk. paper) (DNLM)101560548 BD-DhUL BD-DhUL pcc RM301.4 .S52 2012 QV 38 615.7 SHA Shargel, Leon, Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Andrew B.C. Yu, Susanna Wu-Pong. Applied biopharmaceutics and pharmacokinetics 6th ed. New York : McGraw-Hill, 2012. 1212 xi, 811 p. : 22 cm. ill. ; $ 75.00 Includes bibliographical references and index. Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease. Biopharmaceutics. Pharmacokinetics. Biopharmaceutics. Models, Chemical. Pharmacokinetics. Yu, Andrew B. C., 1945- Wu-Pong, Susanna. 7 cbc orignew 1 ecip 20 y-gencatlg ddc BK xh11 2011-06-17 34146 34146 0 0 ddc 0 615_700000000000000_SHA 0 NFIC 63566 DUSL DUSL GEN 2013-05-28 Purchased 615.7 SHA 479262 2015-01-20 1 2015-01-20 BK 0 0 ddc 0 615_700000000000000_SHA 0 NFIC 63568 DUSL DUSL GEN 2013-05-28 Purchased 615.7 SHA 2015-01-20 2015-01-20 BK