regulatory dynamics underlying the emergence of disease processes Roces, Maria Elena Alvarez-Buylla. creator Martinez-Garcia, Juan Carlos. jt. aut. Davila-Velderrain, Jose. jt. aut. Dominguez-Huttinger, Elisa. jt. aut. Martínez-Sánchez, Mariana Esther. jt. aut. text bibliography sz Cham Springer 2018 monographic eng

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xxi, 258 p. : ill. (chiefly col.) ; 24 cm. This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach. Introduction -- Medical systems biology -- Modeling procedures -- Case of study -- Conclusions and Perspectives -- Bibliography. by María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez. Includes index. Bibliography: p. 215-240. Bioinformatics Mathematical models 570 MOD (DLC) 2018938557 9783319893532 (hbk) 2019752041 DLC 180803 20211004154151.0 21734331 eng