03006cam a22004335i 4500 21734331 BD-DhUL 20211004154151.0 m |o d | cr ||||||||||| 180803s2018 sz a||| b |||1 0|eng 2019752041 9783319893532 (hbk) DLC eng pn rda DLC BD-DhUL 570 MOD Roces, Maria Elena Alvarez-Buylla. Modeling methods for medical systems biology : regulatory dynamics underlying the emergence of disease processes / by María Elena Álvarez-Buylla Roces, Juan Carlos Martínez-García, José Dávila-Velderrain, Elisa Domínguez-Hüttinger, Mariana Esther Martínez-Sánchez. Cham : Springer, 2018. xxi, 258 p. : ill. (chiefly col.) ; 24 cm. Euro 129.99 Advances in experimental medicine and biology ; 1069. Includes index. Bibliography: p. 215-240. Introduction -- Medical systems biology -- Modeling procedures -- Case of study -- Conclusions and Perspectives -- Bibliography. This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach. Description based on publisher-supplied MARC data. Bioinformatics. Mathematical models. Martinez-Garcia, Juan Carlos. jt. aut. Davila-Velderrain, Jose. jt. aut. Dominguez-Huttinger, Elisa. jt. aut. Martínez-Sánchez, Mariana Esther. jt. aut. Print version: Modeling methods for medical systems biology : regulatory dynamics underlying the emergence of disease processes 9783319893532 (DLC) 2018938557 Printed edition: 9783030077488 Printed edition: 9783319893532 Printed edition: 9783319893556 Advances in Experimental Medicine and Biology, 0065-2598 ; 1069 ddc BK 253249 253249 0 0 ddc 0 570_000000000000000_MOD 0 NFIC 386345 DUSL DUSL GEN 2020-03-19 Purchased 570 MOD 518944 2021-01-26 1 BK Biomedical Physics & Technology 0 0 ddc 0 570_000000000000000_MOD 0 NFIC 386346 DUSL DUSL GEN 2020-03-19 Purchased 570 MOD 518945 2021-01-26 2 BK Biomedical Physics & Technology