02779cam a22004095i 4500 21819026 BD-DhUL 20211012143255.0 m |o d | cr ||||||||||| 180627s2018 sz |||| |b |||1 0|eng 2019764757 9783319906942 (hbk) 10.1007/978-3-319-90695-9 doi (DE-He213)978-3-319-90695-9 DLC eng pn rda DLC BD-DhUL PSAK bicssc PSAK thema SCI017000 bisacsh 571.6 STE Stem cell genetics for biomedical research : past, present, and future / edited by Raul Delgado-Morales. Cham : Springer, 2018. xi, 426 p. : ill. ( some col.) ; 24 cm. Euro 139.99 Includes bibliographical references and index. This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer's disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research. Description based on publisher-supplied MARC data. Cell biology. Human genetics. Molecular biology. Delgado-Morales, Raul. ed. Print version: Stem cell genetics for biomedical research : past, present, and future 9783319906942 (DLC) 2018945917 Printed edition: 9783030080761 Printed edition: 9783319906942 Printed edition: 9783319906966 ddc BK 252950 252950 0 0 ddc 0 571_600000000000000_STE 0 NFIC 385955 DUSL DUSL GEN 2020-03-19 Purchased 571.6 STE 518962 2021-01-13 1 2021-01-13 BK Biomedical Physics & Technology 0 0 ddc 0 571_600000000000000_STE 0 NFIC 385956 DUSL DUSL GEN 2020-03-19 Purchased 571.6 STE 518963 2021-01-13 2 BK Biomedical Physics & Technology