02724cam a22003855i 450000100090000000300080000900500170001700600190003400700150005300800410006801000170010902000240012602400350015003500320018504000360021707200170025307200160027007200230028608200160030924501110032526400310043630000490046736500180051650400520053452013710058658800550195765000180201265000200203065000230205070000320207377601250210577600360223077600360226677600360230221819026BD-DhUL20211012143255.0m    |o  d |      cr |||||||||||180627s2018    sz |||| |b   |||1 0|eng    a  2019764757  a9783319906942 (hbk)7 a10.1007/978-3-319-90695-92doi  a(DE-He213)978-3-319-90695-9  aDLCbengepnerdacDLCdBD-DhUL 7aPSAK2bicssc 7aPSAK2thema 7aSCI0170002bisacsh04a571.6 bSTE10aStem cell genetics for biomedical research :bpast, present, and future /cedited by Raul Delgado-Morales.  aCham : bSpringer, c2018.  axi, 426 p. : bill. ( some col.) ; c24 cm.   aEuro b139.99  aIncludes bibliographical references and index.   aThis book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer's disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.  aDescription based on publisher-supplied MARC data. 0aCell biology. 0aHuman genetics. 0aMolecular biology.1 aDelgado-Morales, Raul.eed.08iPrint version:tStem cell genetics for biomedical research : past, present, and futurez9783319906942w(DLC)  201894591708iPrinted edition:z978303008076108iPrinted edition:z978331990694208iPrinted edition:z9783319906966