Mitchell, Maika G. creator author. text bibliography Electronic books. enk London Elsevier Science 2016 monographic eng

electronic resource

1 online resource : illustrations Machine generated contents note: What Is Clinical Utility/Relevance -- Signal Transduction -- Cell Division -- Cell Differentiation -- Apoptosis -- Cell and Tissue Morphogenesis -- Cell Migration -- What Are the Informatics Challenges in Quantitative Cell Biology Imaging? -- Why Are Open Source Approaches Essential? -- Open Source Tools for Data Acquisition, Visualization, Analysis, and Dissemination -- Supporting Open Source Software -- Partnering Commercial and Open Source Efforts -- Summary -- Introduction to Controlled Drug Delivery Systems -- Advantages of Controlled Delivery Systems -- History of Controlled Drug Delivery -- Sustained Release Drug Delivery Systems -- Advantages of Sustained Release Systems -- Sustained Release Mechanisms -- Liposomes in Drug Delivery -- What Are Liposomes? -- Liposomes in Drug Targeting -- Types of Liposome Targeting -- Nanoparticles in Drug Delivery -- Advantages and Disadvantages of Nanoparticles -- Drug Loading Procedures Note continued: Applications of Nanoparticles -- Nanospheres -- What Is Molecular Nanotechnology? -- Background and Definitions -- Evolution of the Biopolymer -- Synthetic Absorbable Polyesters -- Poly(Ortho Esters) -- Poly(Ortho Ester) III -- Poly(Ortho Ester) IV -- Polyanhydrides as Carriers of Drugs -- Bioabsorbable Poly(Ester-Amides) -- Amino Acid-Derived Polymers -- Applications Comments -- Polyphosphazenes as New Biomaterials -- Bacterial Polyesters: Structural Variability in Microbial Synthesis -- Biosynthetic Polysaccharides -- Chitosan -- Pullulan -- Elsinan -- Chemical Modifications of Proteins and Polysaccharides and Its Effect on Enzyme-Catalyzed Degradation -- Red Blood Cells as Drug Carriers -- Introduction -- Drug Loading -- Red Blood Cells as Drug Carriers against Retroviruses -- Polymerization and Characterization of Biopolymers -- Polymerization -- Characterization -- Mathematical Models for Controlled Release Mechanism Note continued: Mixing/Diffusion Process: Flory's Model -- Rubber Elasticity: Simple Mechanical Model -- Dynamic Model of Electrolyte Gel -- Chemical Capacitance Model -- Electric Potential Capacitance Model -- Kinetic Model -- Dextran Sulfate: Pharmaceutical Uses -- References -- Target Drug Delivery and the Blood-Brain Barrier -- Introduction -- History -- Structure and Function -- Transport -- Glucose Transport -- Amino Acid Transport -- Peptide Transport -- Disorders of the Blood-Brain Barrier -- Getting Past the Barrier -- Routes and Methods of Administration -- Nonpharmaceutical Methods -- Tailored and Carrier Drugs -- Mechanical Disruption -- Artificial Cells -- Introduction -- Methods of Preparation -- Microencapsulation of Bioactive Sorbents -- Microencapsulation of Cells or Microorganisms -- Microencapsulation of Genetically Engineered Cells -- Microencapsulation of Enzymes and Multienzyme Systems -- Red Blood Cell Substitutes Note continued: Biodegradable Artificial Cells -- General Discussions -- General Discussion -- Bibliography -- Appendices -- Appendix A: Glossary of Technical Terms -- Appendix B: Chronological History of Nanotechnology -- Chronology of Significant Events in Nanotechnology Research -- Appendix C: List of Symbols -- History and Facts on the Evolution of Nanotechnology -- MITRE Corporation's List of Nanotechnology Research Sites -- DoD Task Force Forecasts for 1998-2020 -- References -- Bibliography -- Computer Aided Design Model Used for 3D Printing -- Model of a Turbine Showing the Benefits of 3D Printing in Industry -- 3D Modeling -- Printing -- Finishing -- Current Uses -- 3D Printing, a Key Technology for Making Biobots -- Synthetic Organs -- Projected Uses in NASA Space Program -- Science Objectives for Everyone -- Space Applications -- Earth Applications -- Operational Requirements -- Operational Protocols -- How the 3D Printer Will Be Useful in the Future Note continued: Fabrication of Tissue-Engineered Constructs -- Bioprinting -- Bioprinting Technologies -- Alginate and Chitosan as Biomaterial -- Fabrication Technologies for Vasculature Network -- Fabrication of Vascular Conduits -- Materials and Methods -- Fabrication Process -- Coaxial Nozzle -- Results -- Discussion and Conclusion -- Dispensing through the Coaxial Nozzle -- Cell Viability Distribution over the Cross Section -- Discussion and Conclusion -- Results -- Evaluation of Media Perfusion Capabilities -- Materials and Methods -- Media Perfusion System -- Embedding a Vasculature System into Bulk Hydrogel -- Perfusion and Diffusional Characterization -- Quantitative Measurement of Small Molecular Diffusivity -- Reference -- Cancer Researchers and Data Mining -- Definition of Data Mining -- Data Mining General Models -- General Application of Data Mining -- Application of Data Mining in Cancer Studies -- Guiding Principles for an Integrated Data Warehouse Note continued: Introduction -- Data Warehouse Architecture -- Building Cancer Data Warehouse -- References -- Telemedicine -- E-health -- Health Systems -- Hospital Information Systems -- Health Information Systems -- Cloud-Based Informatics Platforms -- Application of Cloud Computing in Health Care -- Excel Macros for Data Analysis -- References -- Challenges to Integrating Genomics -- Health Information Technology Infrastructure -- Putting Thoughts into Action -- EHRs as a Research Tool -- The 100,000 Genomes Project -- Advancing Research and Patient Care -- Other Genetic Research Resources -- Opportunities -- Translation of Genomics for Patient Care and Research -- Engaging Patients -- The Platform for Engaging Everyone Responsibly -- Patient Trust, Consent, and Opting In -- Platform-Supported, Complete Learning Cycles -- Simultaneous Learning Cycles -- Health-Care Disparities -- Improving Health with a Knowledge-Based System -- Innovation within Health Systems Note continued: Managing Priorities in a Health System -- Promoting Health Services Research -- Using Genomic Data in the Clinic -- Leveraging EHRs for Genomics -- Creating a Supportive Infrastructure -- Clinical Decision Support -- Managing Big Data -- Insurance and Regulatory Issues -- Data Sharing -- Standards and Scale -- Use Cases -- Potential Next Steps and Considerations -- Possible Next Steps -- EHR Interoperability -- Clinical Decision Support -- Understanding Consumer Value and Preferences -- References -- Future Trends in Cancer Cell Biology and Informatics -- Introduction -- Objective -- Scope -- Non-Scope -- Responsibility -- Specimens -- Specimen Type -- Validation Specimen Collection, Storage, and Preparation -- Instrumentation -- Reagents -- Validation Summary -- Veridex CellTracks AutoPrep Procedure -- Specimen Preparation -- Setup of CellTracks AutoPrep System Run -- Loading AutoPrep -- Unloading Specimens from AutoPrep Note continued: Control Specimen Analysis and QC -- CellTracks Analyzer II� Image Acquisition -- Identification of Control CTCs -- Control Specimen QC -- Clinical Specimen Analysis -- Generate Specimen Reports -- Acceptance/Rejection Criteria for Identification of CTCs -- Rubicon PicoPlex WGA of CTCs -- Initial Preparation of CTCs -- WGA Protocol -- Analyzing Amplification Efficiency Results -- Purifying and Quantifying PicoPlex Products -- The DNA Clean & Concentrator["]-5 Protocol -- DNA Purification Procedure -- LightMix� Kit HER2/neu Oncogene Detection Protocol -- Interpretation of HER2/neu qPCR Results -- CTC Recovery (Total for Each 10 mL Tube of Human Whole Blood) -- Sensitivity and Reproducibility of Veridex CellSearch System -- Sensitivity and Reproducibility of HER2/neu Oncogene Amplification and Detection -- Method Comparison of CTC Enumeration -- Necessary Preparations before Starting the Enrichment Procedure -- Preparation of Washing Buffer Note continued: Enrichment Procedure -- Deviations -- Conclusions -- References -- Appendix -- Friedman Test -- Descriptive Statistics -- Correlation Coefficient -- Passing and Bablok Regression -- Repeated Measures ANOVA -- Repeated Measures ANOVA on Log-Transformed Data. Maika G. Mitchell. Includes bibliographical references and index. Cytology Liposomes Biotechnology Nanoparticles SCIENCE Life Sciences Anatomy & Physiology Cytology Liposomes Biotechnology Nanoparticles Cell Physiological Phenomena QH581.2 571.6 QU 300 0128018763 9780128018767 http://www.sciencedirect.com/science/book/9780128018538 http://www.sciencedirect.com/science/book/9780128018538 IDEBK 160122 20190328114813.0 ocn935642193 eng