09887cam a2200565Ia 4500 ocn935642193 OCoLC 20190328114813.0 m o d cr |n||||||||| 160122s2016 enka ob 001 0 eng d IDEBK eng pn IDEBK N$T YDXCP N$T OCLCO OCLCF OCLCO OPELS CDX TEFOD OCLCQ OCLCO DEBSZ Z5A UPM OCLCQ U3W D6H NAM OCLCO MERER OCLCO OCLCQ 0128018763 (electronic bk.) 9780128018767 (electronic bk.) 9780128018538 0128018534 (OCoLC)935642193 QH581.2 QU 300 SCI 056000 bisacsh 571.6 23 Mitchell, Maika G., author. Cell biology : translational impact in cancer biology and bioinformatics / [electronic resource] Maika G. Mitchell. London : Elsevier Science, 2016. 1 online resource : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Print version record. Machine generated contents note: What Is Clinical Utility/Relevance -- Signal Transduction -- Cell Division -- Cell Differentiation -- Apoptosis -- Cell and Tissue Morphogenesis -- Cell Migration -- What Are the Informatics Challenges in Quantitative Cell Biology Imaging? -- Why Are Open Source Approaches Essential? -- Open Source Tools for Data Acquisition, Visualization, Analysis, and Dissemination -- Supporting Open Source Software -- Partnering Commercial and Open Source Efforts -- Summary -- Introduction to Controlled Drug Delivery Systems -- Advantages of Controlled Delivery Systems -- History of Controlled Drug Delivery -- Sustained Release Drug Delivery Systems -- Advantages of Sustained Release Systems -- Sustained Release Mechanisms -- Liposomes in Drug Delivery -- What Are Liposomes? -- Liposomes in Drug Targeting -- Types of Liposome Targeting -- Nanoparticles in Drug Delivery -- Advantages and Disadvantages of Nanoparticles -- Drug Loading Procedures Note continued: Applications of Nanoparticles -- Nanospheres -- What Is Molecular Nanotechnology? -- Background and Definitions -- Evolution of the Biopolymer -- Synthetic Absorbable Polyesters -- Poly(Ortho Esters) -- Poly(Ortho Ester) III -- Poly(Ortho Ester) IV -- Polyanhydrides as Carriers of Drugs -- Bioabsorbable Poly(Ester-Amides) -- Amino Acid-Derived Polymers -- Applications Comments -- Polyphosphazenes as New Biomaterials -- Bacterial Polyesters: Structural Variability in Microbial Synthesis -- Biosynthetic Polysaccharides -- Chitosan -- Pullulan -- Elsinan -- Chemical Modifications of Proteins and Polysaccharides and Its Effect on Enzyme-Catalyzed Degradation -- Red Blood Cells as Drug Carriers -- Introduction -- Drug Loading -- Red Blood Cells as Drug Carriers against Retroviruses -- Polymerization and Characterization of Biopolymers -- Polymerization -- Characterization -- Mathematical Models for Controlled Release Mechanism Note continued: Mixing/Diffusion Process: Flory's Model -- Rubber Elasticity: Simple Mechanical Model -- Dynamic Model of Electrolyte Gel -- Chemical Capacitance Model -- Electric Potential Capacitance Model -- Kinetic Model -- Dextran Sulfate: Pharmaceutical Uses -- References -- Target Drug Delivery and the Blood-Brain Barrier -- Introduction -- History -- Structure and Function -- Transport -- Glucose Transport -- Amino Acid Transport -- Peptide Transport -- Disorders of the Blood-Brain Barrier -- Getting Past the Barrier -- Routes and Methods of Administration -- Nonpharmaceutical Methods -- Tailored and Carrier Drugs -- Mechanical Disruption -- Artificial Cells -- Introduction -- Methods of Preparation -- Microencapsulation of Bioactive Sorbents -- Microencapsulation of Cells or Microorganisms -- Microencapsulation of Genetically Engineered Cells -- Microencapsulation of Enzymes and Multienzyme Systems -- Red Blood Cell Substitutes Note continued: Biodegradable Artificial Cells -- General Discussions -- General Discussion -- Bibliography -- Appendices -- Appendix A: Glossary of Technical Terms -- Appendix B: Chronological History of Nanotechnology -- Chronology of Significant Events in Nanotechnology Research -- Appendix C: List of Symbols -- History and Facts on the Evolution of Nanotechnology -- MITRE Corporation's List of Nanotechnology Research Sites -- DoD Task Force Forecasts for 1998-2020 -- References -- Bibliography -- Computer Aided Design Model Used for 3D Printing -- Model of a Turbine Showing the Benefits of 3D Printing in Industry -- 3D Modeling -- Printing -- Finishing -- Current Uses -- 3D Printing, a Key Technology for Making Biobots -- Synthetic Organs -- Projected Uses in NASA Space Program -- Science Objectives for Everyone -- Space Applications -- Earth Applications -- Operational Requirements -- Operational Protocols -- How the 3D Printer Will Be Useful in the Future Note continued: Fabrication of Tissue-Engineered Constructs -- Bioprinting -- Bioprinting Technologies -- Alginate and Chitosan as Biomaterial -- Fabrication Technologies for Vasculature Network -- Fabrication of Vascular Conduits -- Materials and Methods -- Fabrication Process -- Coaxial Nozzle -- Results -- Discussion and Conclusion -- Dispensing through the Coaxial Nozzle -- Cell Viability Distribution over the Cross Section -- Discussion and Conclusion -- Results -- Evaluation of Media Perfusion Capabilities -- Materials and Methods -- Media Perfusion System -- Embedding a Vasculature System into Bulk Hydrogel -- Perfusion and Diffusional Characterization -- Quantitative Measurement of Small Molecular Diffusivity -- Reference -- Cancer Researchers and Data Mining -- Definition of Data Mining -- Data Mining General Models -- General Application of Data Mining -- Application of Data Mining in Cancer Studies -- Guiding Principles for an Integrated Data Warehouse Note continued: Introduction -- Data Warehouse Architecture -- Building Cancer Data Warehouse -- References -- Telemedicine -- E-health -- Health Systems -- Hospital Information Systems -- Health Information Systems -- Cloud-Based Informatics Platforms -- Application of Cloud Computing in Health Care -- Excel Macros for Data Analysis -- References -- Challenges to Integrating Genomics -- Health Information Technology Infrastructure -- Putting Thoughts into Action -- EHRs as a Research Tool -- The 100,000 Genomes Project -- Advancing Research and Patient Care -- Other Genetic Research Resources -- Opportunities -- Translation of Genomics for Patient Care and Research -- Engaging Patients -- The Platform for Engaging Everyone Responsibly -- Patient Trust, Consent, and Opting In -- Platform-Supported, Complete Learning Cycles -- Simultaneous Learning Cycles -- Health-Care Disparities -- Improving Health with a Knowledge-Based System -- Innovation within Health Systems Note continued: Managing Priorities in a Health System -- Promoting Health Services Research -- Using Genomic Data in the Clinic -- Leveraging EHRs for Genomics -- Creating a Supportive Infrastructure -- Clinical Decision Support -- Managing Big Data -- Insurance and Regulatory Issues -- Data Sharing -- Standards and Scale -- Use Cases -- Potential Next Steps and Considerations -- Possible Next Steps -- EHR Interoperability -- Clinical Decision Support -- Understanding Consumer Value and Preferences -- References -- Future Trends in Cancer Cell Biology and Informatics -- Introduction -- Objective -- Scope -- Non-Scope -- Responsibility -- Specimens -- Specimen Type -- Validation Specimen Collection, Storage, and Preparation -- Instrumentation -- Reagents -- Validation Summary -- Veridex CellTracks AutoPrep Procedure -- Specimen Preparation -- Setup of CellTracks AutoPrep System Run -- Loading AutoPrep -- Unloading Specimens from AutoPrep Note continued: Control Specimen Analysis and QC -- CellTracks Analyzer II� Image Acquisition -- Identification of Control CTCs -- Control Specimen QC -- Clinical Specimen Analysis -- Generate Specimen Reports -- Acceptance/Rejection Criteria for Identification of CTCs -- Rubicon PicoPlex WGA of CTCs -- Initial Preparation of CTCs -- WGA Protocol -- Analyzing Amplification Efficiency Results -- Purifying and Quantifying PicoPlex Products -- The DNA Clean & Concentrator["]-5 Protocol -- DNA Purification Procedure -- LightMix� Kit HER2/neu Oncogene Detection Protocol -- Interpretation of HER2/neu qPCR Results -- CTC Recovery (Total for Each 10 mL Tube of Human Whole Blood) -- Sensitivity and Reproducibility of Veridex CellSearch System -- Sensitivity and Reproducibility of HER2/neu Oncogene Amplification and Detection -- Method Comparison of CTC Enumeration -- Necessary Preparations before Starting the Enrichment Procedure -- Preparation of Washing Buffer Note continued: Enrichment Procedure -- Deviations -- Conclusions -- References -- Appendix -- Friedman Test -- Descriptive Statistics -- Correlation Coefficient -- Passing and Bablok Regression -- Repeated Measures ANOVA -- Repeated Measures ANOVA on Log-Transformed Data. Cytology. Liposomes Biotechnology. Nanoparticles. SCIENCE Life Sciences Anatomy & Physiology. bisacsh Cytology. fast (OCoLC)fst00886282 Liposomes Biotechnology. fast (OCoLC)fst00999412 Nanoparticles. fast (OCoLC)fst01032624 Cell Physiological Phenomena. Electronic books. ScienceDirect http://www.sciencedirect.com/science/book/9780128018538 247273 247273