04960cam a2200577Ii 4500 ocn933611305 OCoLC 20190328114813.0 m o d cr cnu|||unuuu 160104s2016 enk ob 001 0 eng d N$T eng rda pn N$T N$T OPELS OCLCF UIU YDXCP EBLCP COO CQ$ IDEBK USU CSA LVT S4S Z5A VGM OCLCO MERER OCLCO OCLCQ OCLCA U3W USU OCLCQ D6H FQM OCLCO AU@ OCLCO 933783161 935256261 9780128011744 electronic bk. 0128011742 electronic bk. 0128009640 9780128009642 (OCoLC)933611305 (OCoLC)933783161 (OCoLC)935256261 QR201.V55 V53 2016eb QZ 65 616.9/2507 20 Viral pathogenesis : from basics to systems biology / [electronic resource] edited by Michael G. Katze, Department of Microbiology, University of Washington, Seattle, WA, USA, [and 3 others]. 3rd ed. London, UK : Academic Press, 2016. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file html rda R2 digital library Includes bibliographical references and index. Vendor-supplied metadata. Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Part I: History and essentials of viral pathogenesis -- 1. The human toll of viral diseases / Neal Nathanson -- 2. Historical roots / William C. Summers -- 3. Basic concepts / Robert W. Doms -- 4. Innate immunity / Christine A. Biron -- 5. Adaptive immunity / E. John Wherry and David Masopust -- 6. Aberrant immunity / E. John Wherry and David Masopust -- 7. Patterns of infection / Neal Nathanson and Francisco Gonz�alez-Scarano -- 8. Viral oncogenesis / Nicholas A. Wallace and Denise A. Galloway -- 9. HIV and AIDS / Guido Silvestri and Emily K. Cartwright -- 10. Animal models / Victoria K. Baxter and Diane E. Griffin -- Part II: Systems-level approaches to viral pathogenesis -- 11. Systems virology / Marcus J. Korth and G. Lynn Law -- 12. The virus-host interactome / Monika Schneider, Jeffery R. Johnson, Nevan J. Krogan and Sumit K. Chanda -- 13. Host genetics / Martin T. Ferris, Mark T. Heise and Ralph S. Baric -- 14. Metabolomics and lipidomics / Priscilla L. Yang -- 15. Mathematical modeling / Alan S. Perelson -- Part III: Emergence and control of viral infections -- 16. Emerging viral diseases / James W. Le Duc and Neal Nathanson -- 17. Viral evolution / Adi Stem and Raul Andino -- 18. Viral epidemiology / Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer and William J. Moss -- 19. Viral vaccines / Juliet Morrison and Stanley Plotkin -- 20. Antiviral therapy / Douglas D. Richman and Neal Nathanson -- Part IV: Prizes and predictions for viral pathogenesis -- 21. Breakthrough / Neal Nathanson -- 22. What lies ahead? Virus diseases Pathogenesis. HEALTH & FITNESS / Diseases / General bisacsh MEDICAL / Clinical Medicine bisacsh MEDICAL / Diseases bisacsh MEDICAL / Evidence-Based Medicine bisacsh MEDICAL / Internal Medicine bisacsh Virus diseases Pathogenesis. fast (OCoLC)fst01167751 Viruses pathogenicity. Virus Diseases etiology. Virus Diseases immunology. Electronic books. Electronic books. Katze, Michael G., editor. Original 0128009640 9780128009642 (DLC) 2015946371 (OCoLC)944946460 R2 digital library. ScienceDirect http://www.sciencedirect.com/science/book/9780128009642 247270 247270