07632cam a2200973Ii 4500 ocn930023644 OCoLC 20190328114813.0 m o d cr cnu|||unuuu 151120t20162016enk ob 001 0 eng d N$T eng rda pn N$T YDXCP IDEBK WURST UIU OPELS N$T OCLCF EBLCP COO CDX TXI OCLCO OCLCO CDN OCLCQ OCL OCLCO OCLCQ OCLCA U3W CHVBK WYU LOA ZCU MERUC ICG USU OCLCO COCUF VT2 DKC OCLCO 932332263 934189605 1066620153 1088984620 9780128005521 (electronic bk.) 0128005521 (electronic bk.) 0128005483 (Trade Cloth) 9780128005484 (Trade Cloth) 0128005483 9780128005484 9780128005484 (OCoLC)930023644 (OCoLC)932332263 (OCoLC)934189605 (OCoLC)1066620153 (OCoLC)1088984620 R857.T55 T73 2016eb WO 515 QS 525 HEA 012000 bisacsh HEA 020000 bisacsh MED 004000 bisacsh MED 101000 bisacsh MED 109000 bisacsh MED 029000 bisacsh MED 040000 bisacsh MED 092000 bisacsh 610.28 23 Translating regenerative medicine to the clinic / [electronic resource] edited by: Jeffrey Laurence ; guest editors: Pedro Baptista Anthony Atala, Mary van Beusekom. London : Academic Press, 2016. �2016 1 online resource (xiv, 339 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Advances in translational medicine Academic Press is an imprint of Elsevier. Online resource; title from title details screen (ScienceDirect, viewed December 2, 2015). Front Cover; Translating Regenerative Medicine to the Clinic; Copyright; Contents; Contributors; I -- Introduction; 1 -- Regenerative Medicine: The Hurdles and Hopes; Key Concepts; 1. INTRODUCTION; 2. ON THE ORIGINS OF REGENERATIVE MEDICINE; 3. FROM CELLS AND SCAFFOLDS TO TISSUES AND ORGANS; 4. BIOMATERIALS, TISSUE AND ORGAN BIOENGINEERING; 5. GENE THERAPY; 6. STEM CELL THERAPIES; 7. FUTURE DIRECTIONS; REFERENCES; II -- Biomaterials and Tissue/Organ Bioengineering; 2 -- Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction; Key Concepts; 1. INTRODUCTION. 2. ECM AS A SCAFFOLD FOR REGENERATIVE MEDICINE2.1 The ECM as a Mechanical Substrate; 2.2 ECM Composition; 2.3 Dynamic Reciprocity; 2.4 Bioactive Degradation Products; 2.5 ECM as an Instructive Niche for Stem Cells; 3. DECELLULARIZATION AND FABRICATION METHODS; 4. TRANSLATIONAL APPLICATIONS OF ECM IN REGENERATIVE MEDICINE; 4.1 Esophageal Disease; 4.2 Volumetric Muscle Loss; 4.3 Temporomandibular Joint Meniscectomy; 5. MECHANISMS OF CONSTRUCTIVE REMODELING; 5.1 Mechanical Forces; 5.2 Modulation of the Host Response; 5.3 ECM Scaffold Degradation. 5.4 Undesirable Responses to ECM Scaffold Materials6. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 -- Whole-Organ Bioengineering-Current Tales of Modern Alchemy; Key Concepts; 1. INTRODUCTION; 2. CURRENT STATUS OF ORGAN TRANSPLANTATION; 3. CURRENT STATUS ON ORGAN BIOENGINEERING; 3.1 Liver; 3.2 Intestine; 3.3 Kidney; 3.4 Heart; 3.5 Pancreas; 3.6 Lungs; 4. CURRENT APPLICATIONS FOR BIOENGINEERED ORGANS; 5. CURRENT LIMITATIONS; 5.1 Cell Sources and Expansion; 5.2 Assembly of Patent Vascular Networks; 5.3 Enabling Bioreactor Technologies; 5.4 Regulatory Challenges, Scaling Up, and Other Issues. 6. CONCLUSIONSREFERENCES; 4 -- Regenerative Implants for Cardiovascular Tissue Engineering; 1. INTRODUCTION; 1.1 The Path to a Regenerative Approach; 1.2 Brief Historical Overview of Vascular, Heart Valve, and Heart Implants; 1.2.1 Vascular Implants; 1.2.2 Heart Valve; 1.2.3 Whole Heart; 2. TYPES OF REGENERATIVE IMPLANTS-THE CONTINUITY BRIDGE; 2.1 Synthetic; 2.1.1 Degradable Synthetic Polymers; 2.1.2 Fabrication Methods; 2.2 Biologic; 2.2.1 ECM Gels; 2.2.2 Decellularized Scaffolds; 2.2.3 Hybrid; 3. FUNCTION OF IMPLANTS; 3.1 Implants as a Cell Delivery Vehicle Grown In Vitro. 3.1.1 Endothelial Progenitor Cells and MSCs3.1.2 Embryonic and Inducible Stem Cells; 3.1.3 BM Cells; 3.1.4 Cell Seeding Techniques; 3.2 Implants as an In Situ "Cell-Free" Tissue Forming Device; 3.3 Implants as a Drug Delivery Vehicle; 4. CLINICAL APPLICATIONS IN CARDIOVASCULAR REPAIR; 4.1 Vascular; 4.1.1 Vascular Patch; 4.1.2 Vascular Grafts; 4.2 Heart Valve; 4.3 Heart; 5. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; 5 -- Tissue Engineering and Regenerative Medicine: Gastrointestinal Application; Key Concepts; 1. THE GASTROINTESTINAL TRACT: OVERVIEW; 2. NEURODEGENERATIVE DISEASES OF THE GI TRACT. This review of current methodological tools and experimental approaches used by leading translational researchers, discusses the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration and regeneration of the bone and skin. Pedagogically, it concentrates on the latest knowledge, laboratory techniques and experimental approaches used by research leaders in the field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasising recent innovations, critical barriers to progress, the new tools that are being used to overcome them and specific areas of research that require additional study to advance the field as a whole. Includes bibliographical references and index. Regenerative medicine. Clinical medicine. Biomedical materials. Gene therapy. Tissue engineering. HEALTH & FITNESS Holism. bisacsh HEALTH & FITNESS Reference. bisacsh MEDICAL Alternative Medicine. bisacsh MEDICAL Atlases. bisacsh MEDICAL Essays. bisacsh MEDICAL Family & General Practice. bisacsh MEDICAL Holistic Medicine. bisacsh MEDICAL Osteopathy. bisacsh Biomedical materials. fast (OCoLC)fst00832586 Clinical medicine. fast (OCoLC)fst00864361 Gene therapy. fast (OCoLC)fst00939638 Regenerative medicine. fast (OCoLC)fst01745494 Tissue engineering. fast (OCoLC)fst01151484 Tissue Engineering. (DNLM)D023822 Cell- and Tissue-Based Therapy. (DNLM)D064987 Genetic Therapy. (DNLM)D015316 Clinical Laboratory Techniques. (DNLM)D019411 Translational Medical Research. (DNLM)D057170 Regenerative Medicine methods. (DNLM)D044968Q000379 Electronic books. lcgft Electronic books. Laurence, Jeffrey, editor. Baptista, Pedro (Pedro M.), editor. Atala, Anthony, 1958- editor. Van Beusekom, Mary, editor. Print version: Laurence, Jeffrey. Translating Regenerative Medicine to the Clinic. Saint Louis : Elsevier Science, �2015 9780128005484 (OCoLC)948776104 Advances in translational research. ScienceDirect http://www.sciencedirect.com/science/book/9780128005484 247228 247228