Fraga, Mario. Fernandez, Agustin F. text bibliography Electronic books. Electronic books. enk London Academic Press 2015, �2016 2015 2016 monographic eng

electronic resource

1 online resource. Reviews the technologically-driven study of the oganismal epigenome and associated translational impacts on future prognosis, diagnosis and therapies of disease. With next-generation sequencing technologies shaping our current knowledge of the role of epigenetics in normal development, aging, and disease, Epigenomics in Health and Disease discusses the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. Chapters also explore the latest findings of epigenome-wade research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. With coverage pertinent both to basic biology and translational research, Epigenomics in Health and Disease will be of particular interest for medical and bioscience researches and students seeking current translational knowledge in epigenesis and epigenomics. Key Features Critical reviews provide the means for reviewing and analyzing the epigenome as a whole as well as its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and date analysis Includes coverage of relatively new topics including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging. The role of the genetic code in the DNA methylation landscape formation / Holger Heyn -- DNA methylation microarrays / Marina Bibikova -- Ultra-deep sequencing of bisulfite-modified DNA / Tingting Qin, Yongseok Park, Maria E. Figueroa and Maureen A. Sartor -- Bioinformatics tools in epigenomics studies / Gustavo F. Bay�on, August�in F. Fern�andez and Mario F. Fraga -- Noncoding RNA regulation of health and disease / Nicolas L�eveill�e, Carlos A. Melo and Sonia A. Melo -- Genome-wide DNA methylation changes during aging / Kevin C. Johnson and Brock C. Christensen -- The dynamics of histone modifications during aging / Anthony J Bainor and Gregory David -- Epigenomic studies in epidemiology / Valentina Bollati, Valeria Motta, Simona Iodice and Michele Carugno -- The DNA methylomes of cancer / Ren�ee Beekman, Marta Kulis and Jos�e Ignacio Mart�in-Subero -- Genome-wide epigenetic studies in neurologic diseases / Ashwin Woodhoo -- Epigenetic deregulation in autoimmune disease / Damiana �Alvarez-Errico and Esteban Ballestar -- Genome-wide DNA and histone modification studies in metabolic disease / Charlotte Ling and Tina R�onn -- Clinical applications of epigenomics / Michael A. McDevitt. edited by Mario F. Fraga and Agustin F. Fernandez. Includes index. Includes bibliographical references at the end of each chapters and index. Epigenetics Medical genetics SCIENCE Life Sciences Evolution Epigenetics Medical genetics Epigenomics methods Epigenesis, Genetic Gene Expression Regulation QH450 576.5 QU 460 Fraga, Mario. : Elsevier Science, �2015 (OCoLC)935189889 (DLC) 2015949020 0128004967 9780128004968 0128001402 9780128001400 http://www.sciencedirect.com/science/book/9780128001400 http://www.sciencedirect.com/science/book/9780128001400 IDEBK 151016 20190328114813.0 ocn925286798 eng