05307cam a2200613Ma 4500 ocn925286798 OCoLC 20190328114813.0 m o d cr |n||||||||| 151016t20152016enk ob 001 0 eng d IDEBK eng pn IDEBK N$T OPELS N$T YDXCP OCLCF EBLCP CDX OCLCQ YDX OCLCQ IDB OCLCQ MERUC COO ITD OCLCO OCLCQ U3W OCLCO D6H CHVBK OCLCO AU@ OCLCO UKMGB OCLCQ OCLCO OCLCA CUY ZCU OCLCO ICG USU OCLCO DKC OCLCO 017595343 Uk 929530023 932052201 934623063 957680020 958083503 0128004967 (electronic bk.) 9780128004968 (electronic bk.) 0128001402 9780128001400 9780128001400 0128001402 9780128001400 (OCoLC)925286798 (OCoLC)929530023 (OCoLC)932052201 (OCoLC)934623063 (OCoLC)957680020 (OCoLC)958083503 QH450 QU 460 SCI 027000 bisacsh 576.5 23 Epigenomics in health and disease / [electronic resource] edited by Mario F. Fraga and Agustin F. Fernandez. London : Academic Press, 2015, �2016. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Translational epigenetics series Includes index. Print version record. Includes bibliographical references at the end of each chapters and index. The role of the genetic code in the DNA methylation landscape formation / Holger Heyn -- DNA methylation microarrays / Marina Bibikova -- Ultra-deep sequencing of bisulfite-modified DNA / Tingting Qin, Yongseok Park, Maria E. Figueroa and Maureen A. Sartor -- Bioinformatics tools in epigenomics studies / Gustavo F. Bay�on, August�in F. Fern�andez and Mario F. Fraga -- Noncoding RNA regulation of health and disease / Nicolas L�eveill�e, Carlos A. Melo and Sonia A. Melo -- Genome-wide DNA methylation changes during aging / Kevin C. Johnson and Brock C. Christensen -- The dynamics of histone modifications during aging / Anthony J Bainor and Gregory David -- Epigenomic studies in epidemiology / Valentina Bollati, Valeria Motta, Simona Iodice and Michele Carugno -- The DNA methylomes of cancer / Ren�ee Beekman, Marta Kulis and Jos�e Ignacio Mart�in-Subero -- Genome-wide epigenetic studies in neurologic diseases / Ashwin Woodhoo -- Epigenetic deregulation in autoimmune disease / Damiana �Alvarez-Errico and Esteban Ballestar -- Genome-wide DNA and histone modification studies in metabolic disease / Charlotte Ling and Tina R�onn -- Clinical applications of epigenomics / Michael A. McDevitt. Reviews the technologically-driven study of the oganismal epigenome and associated translational impacts on future prognosis, diagnosis and therapies of disease. With next-generation sequencing technologies shaping our current knowledge of the role of epigenetics in normal development, aging, and disease, Epigenomics in Health and Disease discusses the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. Chapters also explore the latest findings of epigenome-wade research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. With coverage pertinent both to basic biology and translational research, Epigenomics in Health and Disease will be of particular interest for medical and bioscience researches and students seeking current translational knowledge in epigenesis and epigenomics. Key Features Critical reviews provide the means for reviewing and analyzing the epigenome as a whole as well as its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and date analysis Includes coverage of relatively new topics including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging. Epigenetics. Medical genetics. SCIENCE Life Sciences Evolution. bisacsh Epigenetics. fast (OCoLC)fst01893642 Medical genetics. fast (OCoLC)fst01014133 Epigenomics methods. (DNLM)D057890Q000379 Epigenesis, Genetic. (DNLM)D044127 Gene Expression Regulation. (DNLM)D005786 Electronic books. lcgft Electronic books. Fraga, Mario. Fernandez, Agustin F. Print version: Fraga, Mario. Epigenomics in Health and Disease. : Elsevier Science, �2015 9780128001400 (OCoLC)935189889 (DLC) 2015949020 Translational epigenetics series. ScienceDirect http://www.sciencedirect.com/science/book/9780128001400 247191 247191