06074cam a2200649Ii 4500 ocn919087033 OCoLC 20190328114812.0 m o d cr cnu|||unuuu 150824t20162016ne a ob 001 0 eng d N$T eng rda pn N$T YDXCP N$T OCLCO IDEBK CDX UIU OCLCF OCLCO EBLCP OCLCO DEBSZ COO ABH OCLCO CHVBK OCLCO ESU OCLCQ NAM OCLCO MERER OCLCO OCLCQ MERUC OCLCO OCLCA NUI GGVRL Z5A VGM OCLCO OCL UUM OCLCO U3W OCLCO RVA CEF OCLCO OCLCQ OCLCA WYU 101671936 DNLM 923546172 929142666 937530114 1066627783 9780124116207 (electronic bk.) 0124116205 (electronic bk.) 0124115969 9780124115965 9780124115965 0124115969 9780124116207 9780124115965 (OCoLC)919087033 (OCoLC)923546172 (OCoLC)929142666 (OCoLC)937530114 (OCoLC)1066627783 QP86 WT 104 H236 2016 SCI 056000 bisacsh 571.8/78 23 Handbook of the biology of aging / [electronic resource] edited by Matt R. Kaeberlein and George M. Martin. 8th ed. Amsterdam : Elsevier Ltd., 2016. �2016 1 online resource (xvi, 559 pages) : illustrations. text txt rdacontent computer c rdamedia online resource cr rdacarrier Handbooks of aging ; volume 3 Includes bibliographical references and indexes. Online resource; title from PDF title page (EBSCO, viewed August 26, 2015). ""Front Cover""; ""Handbook of the Biology of Aging""; ""Copyright Page""; ""Contents""; ""Foreword""; ""Preface""; ""About the Editors""; ""List of Contributors""; ""I. Basic Mechanisms of Aging: Models and Systems""; ""1 Longevity as a Complex Genetic Trait""; ""Introduction""; ""Defining the Aging Gene-Space""; ""Direct Screens for Genetic Longevity Determinants""; ""RNAi Screens in Nematodes""; ""Knockout Screens in Budding Yeast""; ""Overexpression Screens in Fruit Flies""; ""Leveraging Genetic Diversity to Identify Aging Loci""; ""Mapping Longevity Genes in Human Populations"" ""Mapping Longevity Genes in Mouse Populations""""Mouse�a�?Human Concordance""; ""Age-Associated Gene Expression Studies""; ""Non-Genetic Sources of Complexity""; ""Tissue-Specific Aging""; ""Tissue-Specific Age-Related DNA Methylation""; ""Telomere Shortening and Telomerase""; ""Tissue-Specific Responses of Aging Pathways""; ""Gene�a�?Environment Interaction""; ""Genetic Response to DR""; ""DR: Quantity, Composition, and Timing""; ""Environmental Temperature""; ""Environmental Oxygen and the Hypoxic Response""; ""Other Environmental Factors That Influence Aging"" ""Emerging Tools for Studying Aging as a Complex Genetic Trait""""High-Throughput Lifespan Assays in Yeast and Worms""; ""Genome-Scale Mouse Knockout Collection""; ""Collaborative Cross and Diversity Outbred Mice""; ""Expression QTLs""; ""Aging Biomarkers""; ""Conclusions""; ""References""; ""2 The mTOR Pathway and Aging""; ""Introduction""; ""mTOR Signaling Pathway""; ""Molecular Composition of mTOR Complex""; ""Upstream Regulators of mTOR Complexes""; ""Substrates and Actions of mTORC1""; ""Substrates and Actions of mTORC2"" ""Genetic Modulation of Longevity by TOR Signaling in Model Organisms""""Rapamycin""; ""Rapalogs""; ""Potential Mechanisms of Life Span Extension by mTOR Inhibition""; ""Translation""; ""Autophagy""; ""Anticancer Effect""; ""Stem Cell Maintenance""; ""mTOR in Age-Related Diseases""; ""Cancer""; ""Metabolic Disease""; ""Cardiovascular""; ""Neurodegeneration and Cognitive Decline""; ""Immune Response""; ""Conclusion""; ""References""; ""3 Sirtuins, Healthspan, and Longevity in Mammals""; ""Introduction""; ""Sirtuin-Driven Lifespan Extension in Invertebrates""; ""Sirtuin Enzymatic Activity"" ""Sirtuins and Mammalian Longevity""""SIRT1""; ""SIRT2""; ""SIRT6""; ""Genetic Variation of Human Sirtuins""; ""SIRT1""; ""SIRT3""; ""Sirtuins as Modulators of Responses to CR""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT5""; ""SIRT6""; ""Roles for Sirtuins in Diverse Disease States""; ""Cancer""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT6""; ""SIRT7""; ""Metabolic Syndrome""; ""SIRT1""; ""SIRT2""; ""SIRT3""; ""SIRT4""; ""SIRT5""; ""SIRT6""; ""SIRT7""; ""Cardiovascular Dysfunction""; ""SIRT1""; ""Other Sirtuins""; ""Inflammatory Signaling""; ""Neurodegenerative Disease"" Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussion. Includes bibliographical references and index. Aging Physiological aspects. Aging physiology. (DNLM)D000375Q000502 SCIENCE Life Sciences Anatomy & Physiology. bisacsh Aging Physiological aspects. fast (OCoLC)fst00800323 Electronic books. Electronic book. Kaeberlein, Matt, 1971- editor. Martin, George M., 1927- editior. Print version: Kaeberlein, Matt. Handbook of the Biology of Aging. : Elsevier Science, �2015 9780124115965 Handbooks of aging ; v. 3. ScienceDirect http://www.sciencedirect.com/science/book/9780124115965 247142 247142