05693cam a2200577Ii 4500 ocn918892654 OCoLC 20190328114812.0 m o d cr cnu|||unuuu 150818s2016 cau ob 001 0 eng d N$T eng rda pn N$T OPELS YDXCP N$T OCLCF EBLCP VGM OCLCO MERER OCLCO OCLCQ OCLCA U3W OCLCO D6H CHVBK OCLCO AU@ OCLCO WYU OCLCO OCLCA GBB4C5550 bnb 016938658 Uk 918932218 918994293 923544167 929142275 1066460860 9780127999203 (electronic bk.) 0127999205 (electronic bk.) 9780124201941 0124201946 (OCoLC)918892654 (OCoLC)918932218 (OCoLC)918994293 (OCoLC)923544167 (OCoLC)929142275 (OCoLC)1066460860 QP624.5.M46 QU 58.5 SCI 007000 bisacsh 572.8/645 23 Neidhart, Michel, author. DNA methylation and complex human disease / [electronic resource] Michel Neidhart. Amsterdam : Elsevier, 2016. 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Online resource; title from PDF title page (EBSCO, viewed August 20, 2015). Includes bibliographical references and index. ""Front Cover""; ""DNA Methylation and Complex Human Disease""; ""Copyright Page""; ""Contents""; ""Preface""; ""About the Author""; ""1 DNA Methylation �a�? Introduction""; ""1.1 Epigenetics""; ""1.2 Histone Modifications""; ""1.2.1 Histone Acetylation and Deacetylation""; ""1.2.2 Histone Methylation""; ""1.3 DNA Methylation""; ""1.3.1 DNA Methyltransferases""; ""1.4 Methyl-Binding Domain Proteins""; ""1.5 DNA Demethylation""; ""1.6 DNA Hydroxymethylation""; ""1.7 Differentially Methylated Regions""; ""1.8 Nutriepigenomics""; ""References"" ""2 DNA Methylation and Epigenetic Biomarkers in Cancer""""2.1 Introduction""; ""2.1.1 Diagnosis Biomarkers""; ""2.1.2 Progression Biomarkers""; ""2.1.3 Predictive Biomarkers""; ""2.1.4 Discovery of Novel Biomarkers""; ""2.2 Cancerogenesis""; ""2.3 Epimutations in Cancer""; ""2.3.1 Esophageal Adenocarcinoma""; ""2.3.2 Gastric Cancer""; ""2.3.3 Colorectal Carcinoma""; ""2.3.4 Lynch Syndrome""; ""2.3.5 Endometrial and Ovarian Cancers""; ""2.3.6 Lung Cancer""; ""2.3.7 Glioblastoma""; ""2.3.8 Hematopoietic Cancers""; ""2.4 Conclusion""; ""References"" ""3 DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases""""3.1 Introduction""; ""3.2 Autoimmunity""; ""3.2.1 Type 1 Diabetes""; ""3.2.2 Rheumatoid Arthritis""; ""3.2.3 Systemic Lupus Erythematosis""; ""3.2.4 Inflammatory Bowel Disease, Crohn�a�?s Disease, and Ulcerative Colitis""; ""3.3 Metabolic Diseases""; ""3.3.1 Type 2 Diabetes""; ""3.3.2 Heart Failure""; ""3.4 Developmental Diseases""; ""3.4.1 Imprinting Disorders""; ""3.4.2 Arrhythmia""; ""3.5 Psychiatric Diseases""; ""3.5.1 Major Depressive Disorder""; ""3.5.2 Schizophrenia""; ""3.6 Conclusion""; ""References"" ""4 DNA Methylation and Environmental Factors""""4.1 Introduction""; ""4.2 Impact of the Environment in Early Life""; ""4.2.1 Genomic Imprinting""; ""4.2.2 Beckwith-Wiedemann Syndrome""; ""4.2.3 Assisted Reproductive Technologies""; ""4.2.4 Large Offspring Syndrome""; ""4.3 Nutritional Factors""; ""4.3.1 Gestational Maternal Nutritional Factors""; ""4.3.2 Nutritional Deficiencies""; ""4.4 Adverse Environmental Factors""; ""4.4.1 Environmental Toxicants""; ""4.4.2 Ethanol Consumption""; ""4.4.3 Smoking""; ""4.5 Immune Activation""; ""4.5.1 Asthma and Allergy""; ""4.5.2 Bacterial Infections"" ""4.5.3 Viral Infections""""4.6 Maternal Mood and Experience in Early Life""; ""4.7 Physical Exercise""; ""4.8 Conclusion""; ""References""; ""5 DNA Methylation and Epidemiology""; ""5.1 Introduction""; ""5.2 Endocrine Disrupting Chemicals""; ""5.2.1 Bisphenol-A""; ""5.2.2 Diethylstillbestrol""; ""5.2.3 Cadmium""; ""5.3 Epigenomics and Breast Cancer""; ""5.3.1 RASSF1A""; ""5.3.2 P16/CDKN2A""; ""5.4 Tobacco Smoking""; ""5.4.1 F2RL3, Smoking, and Cardiovascular Diseases""; ""5.4.2 RUNX3, Smoking, Low Birth Weight, and Lung Carcinomas""; ""5.4.3 AHRR, Smoking, and Lung Metastasis"" DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylati. DNA Methylation. Medical genetics. SCIENCE Life Sciences Biochemistry. bisacsh DNA Methylation. fast (OCoLC)fst00886570 Medical genetics. fast (OCoLC)fst01014133 DNA Methylation. (DNLM)D019175 Genetics, Medical. (DNLM)D005826 Electronic books. Electronic book. Print version: Neidhart, Michel. DNA methylation and complex human disease. Amsterdam : Elsevier, 2016 9780124201941 0124201946 (OCoLC)885228983 ScienceDirect http://www.sciencedirect.com/science/book/9780124201941 247136 247136