06139cam a2200601Ii 4500 ocn911179264 OCoLC 20190328114811.0 m o d cr cnu|||unuuu 150618s2015 enk ob 001 0 eng d N$T eng rda pn N$T N$T OCLCO IDEBK OPELS EBLCP OCLCO YDXCP CDX COO OCLCO DEBSZ ABH OCLCO OCLCF OCLCO LVT OCLCO OCLCO OCLCQ CASUM OCLCO OCLCA MERUC OCLCO OCLCA BUF OCLCO UUM OCLCO MERER OCLCO U3W OCLCO D6H OCLCQ CHVBK OCLCQ OCLCO AU@ OCLCO OCLCQ OCLCO OCLCA CUY LOA ZCU OCLCO ICG K6U COCUF OCLCQ DKC 911247236 912406001 9780124199569 (electronic bk.) 0124199569 (electronic bk.) 0124186890 9780124186897 9780124186897 (OCoLC)911179264 (OCoLC)911247236 (OCoLC)912406001 R852 2015 J-145 W 20.5 MED 106000 bisacsh 610.72 23 Maiv�ali, �Ulo, author. Interpreting biomedical science : experiment, evidence, and belief / [electronic resource] �Ulo Maiv�ali. London : Academic Press is an imprint of Elsevier, 2015 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Online resource; title from PDF title page (Ebsco, viewed June 19, 2015). Includes bibliographical references and index. Interpreting Biomedical Science: Experiment, Evidence, and Belief discusses what can go wrong in biological science, providing an unbiased view and cohesive understanding of scientific methods, statistics, data interpretation, and scientific ethics that are illustrated with practical examples and real-life applications. Casting a wide net, the reader is exposed to scientific problems and solutions through informed perspectives from history, philosophy, sociology, and the social psychology of science. The book shows the differences and similarities between disciplines and different eras and illustrates the concept that while sound methodology is necessary for the progress of science, we cannot succeed without a right culture of doing things. Front Cover; Interpreting Biomedical Science: Experiment, Evidence, and Belief; Copyright Page; Contents; Preface; Acknowledgments; Introduction; Science Made Easy; Did the Greeks Get their Math Right but their Science Wrong?; The Scientific Revolution; Deduction and Induction as Two Approaches to Scientific Inference; References; I. What Is at Stake: The Skeptical Argument; 1 Do We Need a Science of Science?; 1.1 Are We Living in the Golden Age of Science?; 1.2 R & D and the Cost of Medicine; 1.3 The Efficiency of Drug Discovery; 1.4 Factors that Endanger the Quality of Medical Evidence. 1.5 The Stability of Evidence-Based Medical Practices1.6 Reproducibility of Basic Biomedical Science; 1.6.1 Genome-Wide Association Studies; 1.6.2 Microarray Studies; 1.6.3 Proteomics; 1.6.4 Small Science; 1.7 Is Reproducibility a Good Criterion of Quality of Research?; 1.8 Is Biomedical Science Self-Correcting?; 1.9 Do We Need a Science of Science?; References; 2 The Basis of Knowledge: Causality and Truth; 2.1 Scientific Realism and Truth; 2.2 Hume's Gambit; 2.3 Kant's Solution; 2.4 Why Induction Is Poor Deduction; 2.5 Popper's Solution; 2.6 Why Deduction Is Poor Induction. 2.7 Does Lung Cancer Cause Smoking?2.8 Correlation, Concordance, and Regression; 2.8.1 Correlation; 2.8.2 Concordance; 2.8.3 Regression; 2.9 From Correlation to Causation; 2.10 From Experiment to Causation; 2.11 Is Causality a Scientific Concept?; References; II. The Method; 3 Study Design; 3.1 Why Do Experiments?; 3.2 Population and Sample; 3.3 Regression to the Mean; 3.4 Why Repeat an Experiment?; 3.5 Technical Versus Biological Replication of Experiments; 3.6 Experimental Controls; 3.6.1 Example 1. Negative Controls; 3.6.2 Example 2. Normalization Controls. 3.6.3 Example 3. Controlling the Controls3.7 Multiplicities; 3.8 Conclusion: How to Design an Experiment; References; 4 Data and Evidence; 4.1 Looking at Data; 4.2 Modeling Data; 4.3 What Is Probability?; 4.3.1 Bayesian Probability; 4.3.2 Frequentist Probability; 4.3.3 Propensity Theory of Probability; 4.4 Assumptions Behind Frequentist Statistical Tests; 4.5 The Null Hypothesis; 4.6 The P value; 4.6.1 What the P Value Is Not; 4.7 Neyman-Pearson Hypothesis Testing; 4.8 Multiple Testing in the Context of NPHT; 4.9 P Value as a Measure of Evidence; 4.10 The "Error Bars." 4.11 Likelihood as an Unbiased Measure of Evidence4.12 Conclusion: Ideologies Behind Some Methods of Statistical Inference; References; 5 Truth and Belief; 5.1 From Long-Run Error Probabilities to Degrees of Belief; 5.2 Bayes Theorem: What Makes a Rational Being?; 5.3 Testing in the Infinite Hypothesis Space: Bayesian Parameter Estimation; 5.4 All Against All: Bayesianism Versus Frequentism Versus Likelihoodism; 5.5 Bayesianism as a Philosophy; 5.6 Bayesianism and the Progress of Science; 5.7 Conclusion to Part II; References; III. The Big Picture; 6 Interpretation. Medicine Research Methodology. Medical sciences Research. MEDICAL Research. bisacsh Medical sciences Research. fast (OCoLC)fst01014611 Medicine Research Methodology. fast (OCoLC)fst01015079 Biomedical Research. Research Design. Philosophy. Electronic books. Electronic books. lcgft Print version: Maiv�ali, �Ulo. Interpreting Biomedical Science : Experiment, Evidence, and Belief. Burlington : Elsevier Science, �2015 9780124186897 ScienceDirect http://www.sciencedirect.com/science/book/9780124186897 ScienceDirect https://www.sciencedirect.com/science/book/9780124186897 247104 247104