Blass, Benjamin E. creator author. text bibliography Electronic books. Electronic book. enk 2015 monographic eng

electronic resource

1 online resource (xv, 574 pages) : illustrations Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicin. Drug discovery and development: an overview of modern methods and principles -- The drug discovery process: from ancient times to the present day -- Classical targets in drug discovery -- In vitro screening systems -- Medicinal chemistry -- In vitro ADME and In vivo pharmacokinetics -- Animal models of disease states -- Safety and toxicology -- Basics of clinical trials -- Translational medicine and biomarkers -- Organizational considerations and trends in the pharmaceutical industry -- Intellectual property and patents in drug discovery -- Case studies in drug discovery. Benjamin E. Blass. Includes bibliographical references. Drug development Drugs Design MEDICAL / Pharmacology Drug development Drugs Design Chimie pharmaceutique Chimie bioorganique Pharmacologie mol�eculaire M�edicaments Conception Drug Discovery Drug Evaluation RM301.25 .B53 2015eb 615/.19 2015 G-397 QV 745 44.38 Blass, Benjamin E. Amsterdam [Netherlands] ; Boston [Massachusetts] : Elsevier/AP, Academic Press is an imprint of Elsevier, [2015] [Enhanced Credo edition] (OCoLC)948018410 9780124115255 012411525X http://www.sciencedirect.com/science/book/9780124115088 http://www.sciencedirect.com/science/book/9780124115088 N$T 150428 20190328114811.0 ocn908103132 eng