05337cam a2200553Ii 4500 ocn905649781 OCoLC 20190328114810.0 m o d cr mn||||||||| 150326t20152015enka ob 001 0 eng d N$T eng rda pn N$T N$T OPELS BTCTA CDX IDEBK OCLCF OSU E7B EBLCP YDXCP DEBSZ ABH LVT Z5A OCLCQ MERUC SAV OCLCO OCLCA WRM OCLCO U3W OCLCO D6H AU@ OCLCQ OCLCO WYU OCLCO OCLCA 101664503 DNLM 908042071 1066453312 9780128014912 (electronic bk.) 0128014911 (electronic bk.) 9780128014110 0128014113 (OCoLC)905649781 (OCoLC)908042071 (OCoLC)1066453312 RM301.5 .T46 2015eb 2015 G-769 QV 38 MED 071000 bisacsh 615.7 23 Thorsteinn Loftsson, author. Essential pharmacokinetics : a primer for pharmaceutical scientists / [electronic resource] Thorsteinn Loftsson. Amsterdam ; Boston : Elsevier Academic Press, 2015 �2015 1 online resource (vii, 170 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Includes bibliographical references and index. Print version record. Front Cover; Essential Pharmacokinetics; Copyright Page; Contents; Preface; 1 Introduction; 1.1 Some Basic Concepts; 1.2 Pharmacokinetic Models; 1.3 Population Pharmacokinetics; References; 2 Basic Concepts of Pharmacokinetics; 2.1 One-Compartment Open Model; 2.1.1 IV Bolus Injection; 2.1.2 IV Infusion; 2.2 Two-Compartment Open Model; 2.2.1 IV Bolus Injection; 2.2.2 IV Infusion; 2.3 Three-Compartment Open Model; 2.4 Pharmacokinetics of Drug Absorption; 2.4.1 One-Compartment Open Model with Zero-Order Drug Absorption; 2.4.2 One-Compartment Open Model with First-Order Drug Absorption. 2.4.3 One-Compartment Open Model with Urine Sample Collection2.4.4 Two-Compartment Open Model with First-Order Drug Absorption; 2.4.5 Flip-Flop Pharmacokinetics; 2.5 Bioavailability; 2.6 Drug Distribution, Protein Binding, and Clearance; 2.6.1 Protein Binding; 2.6.2 Clearance; 2.7 Multiple-Dose Regimens; 2.7.1 Multiple-Dosage by IV Bolus Injection and One-Compartment Open Model; 2.7.2 Multiple-Dosage by Oral Administration and One-Compartment Open Model; 2.7.3 Loading Dose; 2.8 Nonlinear Pharmacokinetics; 2.8.1 Michaelis-Menten Equation; 2.9 Drug Metabolism. 2.10 Drug Permeation Through Biomembranes and Drug Transporters2.10.1 Biomembranes; 2.10.2 Passive Transport Through Mucosa; References; 3 Physicochemical Properties and Pharmacokinetics; 3.1 Lipinski's Rule of Five; 3.2 The Biopharmaceutics Classification System; 3.3 The Biopharmaceutics Drug Disposition Classification System; 3.4 Metabolizability, Soft Drugs, and Prodrugs; 3.5 Pharmacokinetics of Excipients; References; 4 Drug Pharmacokinetics After Alternative Routes of Administration; 4.1 Fentanyl Transdermal Patch; 4.2 Estradiol Sublingual Tablets; 4.3 Diazepam Suppositories. 4.4 Midazolam Nasal Spray4.5 Pulmonary Delivery (Inhalation) and Subcutaneous Injection of Insulin; 4.6 Topical Delivery of Dexamethasone to the Eye; References; 5 Pharmacologic Response and Drug Dosage Adjustments; 5.1 Therapeutic Drug Monitoring; 5.2 Dosage Adjustments; 5.3 Pharmacodynamics; 6 The Effect of Food and Excipients on Drug Pharmacokinetics; References; 7 Practice Problems; 7.1; 7.2; 7.3; 7.4; 7.5; 7.6; 7.7; 7.8; 7.9; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; References; Appendix I: Answers to Problems in Chapter 7; 7.1; A; B; C; D; E; F; G; 7.2; A; B; C; 7.3; A; B; C; 7.4. 7.57.6; A; B; 7.7; A; B; C; 7.8; A; B; C; 7.9; A; B; C; 7.10; 7.11; 7.12; 7.13; 7.14; 7.15; 7.16; 7.17; Appendix II: Symbols and Abbreviations; Index. Pharmacokinetics. MEDICAL Pharmacology. bisacsh Pharmacokinetics. fast (OCoLC)fst01060250 Pharmacokinetics. (DNLM)D010599 Electronic books. Electronic book. Print version: Thorsteinn Loftsson. Essential pharmacokinetics. Amsterdam ; Boston : Elsevier Academic Press, �2015 9780128014110 ScienceDirect http://www.sciencedirect.com/science/book/9780128014110 247061 247061