Tohen, Mauricio editor. Bowden, Charles L. editor. Nierenberg, Andrew A. (Andrew Alan) 1955- editor. Geddes, John R. editor. text bibliography Electronic book. Electronic books. Electronic books. enk 2015 monographic eng

electronic resource

1 online resource Poor clinical trial designs result in failed studies wasting hundreds of thousands of dollars in research funds. Poor clinical trial designs limit the rapid advancement of cures for disorders. Yet it's relatively easy to avoid classic poor designs via education about what constitutes good design and what the potential outcomes are for any shortcuts taken. The proposed book outlines the classic problems that researchers are faced with in designing clinical trials, whether its money, selection of subjects, regulatory issues etc, and how best to address them for the most definitive and generalizable results. This book is specific to clinical trial issues in psychiatric research, and comes from a task force in Bipolar Research. The contents herein were identified as the most major issues in psychiatric research. Authored by international contributors from academia, industry, regulatory agencies, and advocacy groups, this book summarizes problems in clinical design and the results of same, and whether and how the results can be applied into clinical practice. <P>Preface</p> <p>Chapter 1: Clinical Trial Design of Maintenance Treatments in Bipolar Disorder Mauricio Tohen</p> <p>Chapter 2: Meta-Analysis of Clinical Trials in Bipolar Disorder John R. Geddes</p> <p>Chapter 3: Effectiveness Trials in Bipolar Disorders Andrew A. Nierenberg</p> <p>Chapter 4: Long-Term Treatment of Mood Disorders: Follow-Up of Acute Treatment Phase Studies Versus Continuation and Maintenance Phase Studies, and Enriched Versus Non-Enriched Designs Willem A. Nolen and Heinz Grunze</p> <p>Chapter 5: The Role of Noninferiority Designs in Bipolar Disorder Clinical Trials Edward Vieta and N�uria Cruz</p> <p>Chapter 6: The Use of Mixed Methods in Drug Discovery: Integrating Qualitative Methods into Clinical Trials Michael Berk, Rene�e Otmar, Olivia Dean, Lesley Berk and Erin Michalak</p> <p>Chapter 7: Sequential Multiple Assignment Randomized Treatment (SMART): Designs in Bipolar Disorder Clinical Trials Charles L. Bowden and Vivek Singh</p> <p>Chapter 8: Novel Study Designs for Clinical Trials in Mood Disorders Hong Jin Jeon and Maurizio Fava</p> <p>Chapter 9: Rating Scales in Bipolar Disorder Martha Sajatovic, Peijun Chen and Robert C. Young</p> <p>Chapter 10: Clinical Applicability of Results from Drug Trials in Bipolar Disorder -- An Attempt to Shed Light on a Complex Issue Rasmus Wentzer Licht</p> <p>Chapter 11: Clinical Trials in Developing Countries: Challenges in Design, Execution, and Regulation Chittaranjan Andrade and Tim Appaiah</p> edited by Mauricio Tohen, Charles L. Bowden, Andrew A. Nierenberg, John R. Geddes. Includes bibliographical references and index. Affective disorders Manic-depressive illness PSYCHOLOGY Psychopathology Bipolar Disorder Affective disorders Manic-depressive illness Bipolar Disorder therapy Mood Disorders therapy Clinical Trials as Topic RC512 .C55 2015eb 616.89 2015 F-907 WM 207 London, England : Academic Press, c2015 xi, 179 pages 2014946465 9780124051768 0124051766 2015458943 http://www.sciencedirect.com/science/book/9780124051706 http://www.sciencedirect.com/science/book/9780124051706 N$T 150127 20190328114810.0 ocn900781265 eng