05043cam a2200601Ii 4500 ocn900781265 OCoLC 20190328114810.0 m o d cr cnu|||unuuu 150127s2015 enk ob 001 0 eng d 2015458943 N$T eng rda pn N$T IDEBK N$T UIU OPELS E7B YDXCP OCLCF VLB ABH OCLCQ WRM U3W CHVBK AU@ OCLCQ OCLCO WYU OCLCO OCLCA TKN CUY LOA ZCU MERUC MERER ICG K6U COCUF OCLCQ VT2 DKC 101662180 DNLM 1066445834 1088979503 9780124051768 (electronic bk.) 0124051766 (electronic bk.) 9780124051706 0124051707 (OCoLC)900781265 (OCoLC)1066445834 (OCoLC)1088979503 RC512 .C55 2015eb 2015 F-907 WM 207 PSY 022030 bisacsh 616.89 23 Clinical trial design challenges in mood disorders / [electronic resource] edited by Mauricio Tohen, Charles L. Bowden, Andrew A. Nierenberg, John R. Geddes. London, UK : Academic Press, [2015] 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Vendor-supplied metadata. Includes bibliographical references and index. Poor clinical trial designs result in failed studies wasting hundreds of thousands of dollars in research funds. Poor clinical trial designs limit the rapid advancement of cures for disorders. Yet it's relatively easy to avoid classic poor designs via education about what constitutes good design and what the potential outcomes are for any shortcuts taken. The proposed book outlines the classic problems that researchers are faced with in designing clinical trials, whether its money, selection of subjects, regulatory issues etc, and how best to address them for the most definitive and generalizable results. This book is specific to clinical trial issues in psychiatric research, and comes from a task force in Bipolar Research. The contents herein were identified as the most major issues in psychiatric research. Authored by international contributors from academia, industry, regulatory agencies, and advocacy groups, this book summarizes problems in clinical design and the results of same, and whether and how the results can be applied into clinical practice. Preface Chapter 1: Clinical Trial Design of Maintenance Treatments in Bipolar Disorder Mauricio Tohen Chapter 2: Meta-Analysis of Clinical Trials in Bipolar Disorder John R. Geddes Chapter 3: Effectiveness Trials in Bipolar Disorders Andrew A. Nierenberg Chapter 4: Long-Term Treatment of Mood Disorders: Follow-Up of Acute Treatment Phase Studies Versus Continuation and Maintenance Phase Studies, and Enriched Versus Non-Enriched Designs Willem A. Nolen and Heinz Grunze Chapter 5: The Role of Noninferiority Designs in Bipolar Disorder Clinical Trials Edward Vieta and N�uria Cruz Chapter 6: The Use of Mixed Methods in Drug Discovery: Integrating Qualitative Methods into Clinical Trials Michael Berk, Rene�e Otmar, Olivia Dean, Lesley Berk and Erin Michalak Chapter 7: Sequential Multiple Assignment Randomized Treatment (SMART): Designs in Bipolar Disorder Clinical Trials Charles L. Bowden and Vivek Singh Chapter 8: Novel Study Designs for Clinical Trials in Mood Disorders Hong Jin Jeon and Maurizio Fava Chapter 9: Rating Scales in Bipolar Disorder Martha Sajatovic, Peijun Chen and Robert C. Young Chapter 10: Clinical Applicability of Results from Drug Trials in Bipolar Disorder -- An Attempt to Shed Light on a Complex Issue Rasmus Wentzer Licht Chapter 11: Clinical Trials in Developing Countries: Challenges in Design, Execution, and Regulation Chittaranjan Andrade and Tim Appaiah Affective disorders. Manic-depressive illness. PSYCHOLOGY Psychopathology Bipolar Disorder. bisacsh Affective disorders. fast (OCoLC)fst00798861 Manic-depressive illness. fast (OCoLC)fst01007706 Bipolar Disorder therapy. (DNLM)D001714Q000628 Mood Disorders therapy. (DNLM)D019964Q000628 Clinical Trials as Topic. (DNLM)D002986 Electronic book. Electronic books. Electronic books. lcgft Tohen, Mauricio, editor. Bowden, Charles L., editor. Nierenberg, Andrew A. (Andrew Alan), 1955- editor. Geddes, John R., editor. Print version: Clinical trial design challenges in mood disorders. London, England : Academic Press, c2015 xi, 179 pages 9780124051706 2014946465 ScienceDirect http://www.sciencedirect.com/science/book/9780124051706 247039 247039