Honj�o, Tasuku editor. Reth, Michael editor. Radbruch, A. (Andreas) editor. Alt, Frederick W. editor. text bibliography Electronic books. enk 2015 2nd ed. monographic eng

electronic resource

1 online resource (xxiii 563 pages) : color illustrations Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with update. Front Cover; Molecular Biology of B Cells; Copyright; Dedication; Contents; Preface; Contributors; Chapter 1 -- The Structure and Regulation of the Immunoglobulin Loci; 1. INTRODUCTION; 2. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 3. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS; 4. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS; 5. B CELL DEVELOPMENT AND REGULATION OF V(D)J RECOMBINATION; 6. JUNCTIONAL DIVERSITY; 7. COMBINATORIAL DIVERSITY; 8. NONCODING TRANSCRIPTION AND IMMUNOGLOBULIN LOCUS REARRANGEMENT. 9. THE PROCESS OF DH-JH RECOMBINATION10. EPIGENETICS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 11. INSULATORS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 12. 3D STRUCTURE AND COMPACTION OF THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 13. CONCLUSION; REFERENCES; Chapter 2 -- The Mechanism of V(D)J Recombination; 1. OVERVIEW; 2. ANTIGEN RECEPTOR GENE ASSEMBLY; 3. RECOMBINATION SIGNAL SEQUENCES; 4. BIOCHEMISTRY OF V(D)J CLEAVAGE; 5. RAG1 AND RAG2; 6. A ROLE FOR HMGB1 IN V(D)J RECOMBINATION; 7. RECOMBINATION COMPLEXES: ANALYSIS OF STOICHIOMETRY AND ORGANIZATION. 8. V(D)J RECOMBINATION IS TIGHTLY REGULATED DURING LYMPHOCYTE DEVELOPMENT9. ACCESSIBILITY MODEL OF REGULATION; 10. OVERVIEW OF CHROMATIN STRUCTURE; 11. REGULATION BY NUCLEOSOME STRUCTURE AND HISTONE ACETYLATION; 12. REGULATION BY HISTONE METHYLATION; 13. HOW IS THE CHROMATIN STRUCTURE OF ANTIGEN RECEPTOR LOCI DEVELOPMENTALLY REGULATED?; 14. ADDITIONAL LAYERS OF REGULATION; 15. REGULATION OF V(D)J RECOMBINATION: SUMMARY; 16. ONCOGENIC LESIONS IN LYMPHOID NEOPLASMS: THE PRICE OF A DIVERSE ANTIGEN RECEPTOR REPERTOIRE; 17. PROPOSED MECHANISMS UNDERLYING RAG-MEDIATED GENOMIC LESIONS. 18. REGULATORY CONTROLS PROPOSED TO SUPPRESS RAG-MEDIATED GENOMIC INSTABILITY19. V(D)J RECOMBINATION ERRORS AS PATHOGENIC LESIONS IN LYMPHOID NEOPLASMS: SUMMARY; REFERENCES; Chapter 3 -- Transcriptional Regulation of Early B Cell Development; 1. PU. 1 SETS THE STAGE FOR LYMPHOID AND MYELOID DEVELOPMENT; 2. LINEAGE PRIMING IN LYMPHOID PROGENITORS BY IKAROS; 3. E2A REGULATES THE CHROMATIN LANDSCAPE TO PROMOTE GENE EXPRESSION IN B CELL DEVELOPMENT; 4. E2A IS INHIBITED BY ID PROTEINS; 5. INTERLEUKIN-7/STAT5 SIGNALING PROVIDES AN EARLY SIGNAL FOR B CELL LINEAGE SPECIFICATION. 6. EARLY B CELL FACTOR: CENTRAL COORDINATOR OF B CELL DEVELOPMENT7. COLLABORATION BETWEEN EBF1 AND FOXO1; 8. REGULATION OF THE B CELL-SPECIFIC PROGRAM BY PAX5; 9. REGULATION OF B LINEAGE COMMITMENT; 10. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; Chapter 4 -- Relationships among B Cell Populations Revealed by Global Gene Analysis; 1. INTRODUCTION; 2. GENE PROFILE CHANGES WITH B CELL MATURATION SUGGEST AN ORDERING OF TRANSITIONAL STAGES; 3. DISTINCTIONS IN GENE NETWORKS ACTIVATED IN MATURE B CELL POPULATIONS. edited by Frederick W. Alt, Tasuku Honjo, Andreas Radbruch, Michael Reth. Includes bibliographical references and index. Molecular immunology B cells B cells Differentiation Molecular aspects Immunoglobulins Immunoglobulin genes B-Lymphocytes Immunoglobulins Cell Differentiation physiology HEALTH & FITNESS Diseases General MEDICAL Clinical Medicine MEDICAL Diseases MEDICAL Evidence-Based Medicine MEDICAL Internal Medicine B cells B cells Differentiation Molecular aspects Immunoglobulin genes Immunoglobulins Molecular immunology QR185.6 616.07 616.0798 Online Book Boston, Massachusetts : Elsevier, [2015] 9780123984906 0123984904 0123979331 9780123979339 http://www.sciencedirect.com/science/book/9780123979339 http://www.sciencedirect.com/science/book/9780123979339 EBLCP 141018 20190328114809.0 ocn893332893 eng