06360cam a2200769Ii 4500 ocn893332893 OCoLC 20190328114809.0 m o d cr cnu---unuuu 141018s2015 enka ob 001 0 eng d EBLCP eng rda pn EBLCP N$T GZM YDXCP OCLCO UIU OCLCQ OCLCO N$T COO TPH DEBSZ ITD OCLCF UAB OCLCO MERER OCLCO OCLCQ VGM OCLCO OCLCQ MERUC D6H OCLCO OCLCQ AU@ OCLCQ UBY 9780123984906 (electronic bk.) 0123984904 (electronic bk.) 0123979331 9780123979339 9780123979339 (OCoLC)893332893 QR185.6 Online Book HEA 039000 bisacsh MED 014000 bisacsh MED 022000 bisacsh MED 112000 bisacsh MED 045000 bisacsh 616.07 616.0798 Molecular biology of B cells / [electronic resource] edited by Frederick W. Alt, Tasuku Honjo, Andreas Radbruch, Michael Reth. 2nd ed. London : Elsevier Science, 2015. 1 online resource (xxiii 563 pages) : color illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Online resource; title from PDF title page (ScienceDirect, viewed on November 6, 2014). Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with update. Front Cover; Molecular Biology of B Cells; Copyright; Dedication; Contents; Preface; Contributors; Chapter 1 -- The Structure and Regulation of the Immunoglobulin Loci; 1. INTRODUCTION; 2. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 3. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN KAPPA LIGHT CHAIN LOCUS; 4. GENOMIC ORGANIZATION OF THE MOUSE IMMUNOGLOBULIN LAMBDA LIGHT CHAIN LOCUS; 5. B CELL DEVELOPMENT AND REGULATION OF V(D)J RECOMBINATION; 6. JUNCTIONAL DIVERSITY; 7. COMBINATORIAL DIVERSITY; 8. NONCODING TRANSCRIPTION AND IMMUNOGLOBULIN LOCUS REARRANGEMENT. 9. THE PROCESS OF DH-JH RECOMBINATION10. EPIGENETICS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 11. INSULATORS AND IMMUNOGLOBULIN LOCUS REARRANGEMENT; 12. 3D STRUCTURE AND COMPACTION OF THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS; 13. CONCLUSION; REFERENCES; Chapter 2 -- The Mechanism of V(D)J Recombination; 1. OVERVIEW; 2. ANTIGEN RECEPTOR GENE ASSEMBLY; 3. RECOMBINATION SIGNAL SEQUENCES; 4. BIOCHEMISTRY OF V(D)J CLEAVAGE; 5. RAG1 AND RAG2; 6. A ROLE FOR HMGB1 IN V(D)J RECOMBINATION; 7. RECOMBINATION COMPLEXES: ANALYSIS OF STOICHIOMETRY AND ORGANIZATION. 8. V(D)J RECOMBINATION IS TIGHTLY REGULATED DURING LYMPHOCYTE DEVELOPMENT9. ACCESSIBILITY MODEL OF REGULATION; 10. OVERVIEW OF CHROMATIN STRUCTURE; 11. REGULATION BY NUCLEOSOME STRUCTURE AND HISTONE ACETYLATION; 12. REGULATION BY HISTONE METHYLATION; 13. HOW IS THE CHROMATIN STRUCTURE OF ANTIGEN RECEPTOR LOCI DEVELOPMENTALLY REGULATED?; 14. ADDITIONAL LAYERS OF REGULATION; 15. REGULATION OF V(D)J RECOMBINATION: SUMMARY; 16. ONCOGENIC LESIONS IN LYMPHOID NEOPLASMS: THE PRICE OF A DIVERSE ANTIGEN RECEPTOR REPERTOIRE; 17. PROPOSED MECHANISMS UNDERLYING RAG-MEDIATED GENOMIC LESIONS. 18. REGULATORY CONTROLS PROPOSED TO SUPPRESS RAG-MEDIATED GENOMIC INSTABILITY19. V(D)J RECOMBINATION ERRORS AS PATHOGENIC LESIONS IN LYMPHOID NEOPLASMS: SUMMARY; REFERENCES; Chapter 3 -- Transcriptional Regulation of Early B Cell Development; 1. PU. 1 SETS THE STAGE FOR LYMPHOID AND MYELOID DEVELOPMENT; 2. LINEAGE PRIMING IN LYMPHOID PROGENITORS BY IKAROS; 3. E2A REGULATES THE CHROMATIN LANDSCAPE TO PROMOTE GENE EXPRESSION IN B CELL DEVELOPMENT; 4. E2A IS INHIBITED BY ID PROTEINS; 5. INTERLEUKIN-7/STAT5 SIGNALING PROVIDES AN EARLY SIGNAL FOR B CELL LINEAGE SPECIFICATION. 6. EARLY B CELL FACTOR: CENTRAL COORDINATOR OF B CELL DEVELOPMENT7. COLLABORATION BETWEEN EBF1 AND FOXO1; 8. REGULATION OF THE B CELL-SPECIFIC PROGRAM BY PAX5; 9. REGULATION OF B LINEAGE COMMITMENT; 10. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; Chapter 4 -- Relationships among B Cell Populations Revealed by Global Gene Analysis; 1. INTRODUCTION; 2. GENE PROFILE CHANGES WITH B CELL MATURATION SUGGEST AN ORDERING OF TRANSITIONAL STAGES; 3. DISTINCTIONS IN GENE NETWORKS ACTIVATED IN MATURE B CELL POPULATIONS. Molecular immunology. B cells. B cells Differentiation Molecular aspects. Immunoglobulins. Immunoglobulin genes. B-Lymphocytes. Immunoglobulins. Cell Differentiation physiology. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh B cells. fast (OCoLC)fst00824789 B cells Differentiation Molecular aspects. fast (OCoLC)fst00824791 Immunoglobulin genes. fast (OCoLC)fst00967959 Immunoglobulins. fast (OCoLC)fst00967961 Molecular immunology. fast (OCoLC)fst01024811 Electronic books. Honj�o, Tasuku, editor. Reth, Michael, editor. Radbruch, A. (Andreas), editor. Alt, Frederick W., editor. Print version: Molecular biology of B cells. Boston, Massachusetts : Elsevier, [2015] 9780123979339 ScienceDirect http://www.sciencedirect.com/science/book/9780123979339 246969 246969