05143cam a2200505Ii 4500 ocn893128253 OCoLC 20190328114809.0 m o d cr cnu---unuuu 141016t20142015ne o 000 0 eng d N$T eng rda pn N$T YDXCP UKMGB UIU OCLCF EBLCP OCLCQ DEBSZ OCLCQ U3W MERUC D6H OCLCQ WYU 016911996 Uk 016914121 Uk 893332896 9780123978905 (electronic bk.) 0123978904 (electronic bk.) 9780123978844 (OCoLC)893128253 (OCoLC)893332896 QH324.2 SCI 007000 bisacsh 572.80285 23 Vodovotz, Yoram, author. Translational systems biology : concepts and practice for the future of biomedical research / [electronic resource] Yoram Vodovotz, Gary An. Amsterdam : Academic Press, an imprint of Elsevier, [2014] �2015 1 online resource text txt rdacontent computer c rdamedia online resource cr rdacarrier Online resource; title from PDF title page (EBSCO, viewed October 16, 2014). Front Cover; Translational Systems Biology; Copyright Page; Dedication; Contents; Preface; Acknowledgments; I. Introduction and Overview; 1.1 Interesting Times: The Translational Dilemma and the Need for Translational Systems Biology of Inflammation; Primary Goal: Facilitate the Translation of Basic Biomedical Research to the Implementation of Effective Clinical Therapeut ... ; How to Approach This Book; References; II. The Current Landscape: Where It Came From, How We Got Here, and What Is Wrong. 2.1 A Brief History of the Philosophical Basis of the Scientific Endeavor: How We Know What We Know, and How to Know MoreModels in the Cave; Earth at the Center: A Reasonable Mistake, and an Unreasonable Perpetuation; The Scientific Method of Francis Bacon; Newton: The (Justifiable) Origins of Physics Envy; The Problem of Induction: Hume's Empiricism; Logic and Its True/False Promise: Logical Positivism, Godel and Popper; Charles Peirce Suggests Taking a Guess: The Abductive Approach; The Mapping Problem: Back to Plato?; Suggested Additional Readings. 2.2 A Brief History of Biomedical Research up to the Molecular Biology RevolutionReference; Suggested Additional Readings; 2.3 Biomedical Research Since the Molecular Revolution: An Embarrassment of Riches; References; 2.4 Randomized Clinical Trials: A Bridge Too Far?; References; 2.5 Complexity in Biomedical Research: Mysticism Versus Methods; References; Suggested Additional Readings; 2.6 Human Nature, Politics, and Translational Inertia; Setting the Table with Bacon; An Embarrassment of Riches; Shibboleths in Science: The Problem with Pedigrees. Incentives and the Professionalization of ScienceDeep Pockets, with Holes: The Pharma Conundrum; Reference; III. Translational Systems Biology: How We Propose to Fix the Problems of the Current Biomedical Research Landscape; 3.1 Towards Translational Systems Biology of Inflammation; Primary Goal: Facilitate the Translation of Basic Biomedical Research to the Implementation of Effective Clinical Therapeut ... ; References; 3.2 Dynamic Knowledge Representation and the Power of Model Making; References. 3.3 A Roadmap for a Rational Future: A Systematic Path for the Design and Implementation of New TherapeuticsRational Evaluation of Drug Candidates: Knowing What Might Work, and More Importantly, What Won't; In silico Clinical Trials: Crossing the "Bridge Too Far"; From Populations to Individuals: Personalizing Medical Care; References; IV. Tools and Implementation of Translational Systems Biology: This is How We Do It; 4.1 From Data to Knowledge in Translational Systems Biology: An Overview of Computational Approaches Across the Scientific ... Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the inte. Systems biology. SCIENCE Life Sciences Biochemistry. bisacsh Systems biology. fast (OCoLC)fst01745552 Electronic books. An, Gary, author. Print version: Vodovotz, Yoram. Translational Systems Biology : Concepts and Practice for the Future of Biomedical Research. Burlington : Elsevier Science, �2014 9780123978844 ScienceDirect http://www.sciencedirect.com/science/book/9780123978844 246968 246968