06176cam a2200709Mi 4500 ocn890162866 OCoLC 20190328114808.0 m o d cr ||||||||||| 140915s2014 enk o 000 0 eng d 2014950424 UKMGB eng rda pn UKMGB N$T OPELS YDXCP CHVBK OCLCF IDEBK EBLCP OCLCQ CNCGM MERER OCLCQ OCLCO ITD OCLCO OCLCQ U3W D6H OCLCQ OTZ WYU LOA CUY ZCU USU MERUC OCLCO ICG K6U COCUF OCLCQ VT2 DKC 016869524 Uk 016856985 Uk 898422306 1066443727 1088966405 9781908818683 (electronic bk.) 1908818689 (electronic bk.) 9781907568473 (hbk.) 1907568476 (print) (OCoLC)890162866 (OCoLC)898422306 (OCoLC)1066443727 (OCoLC)1088966405 RC661.I6 S66 2014 2015 A-997 WK 820 HEA 039000 bisacsh MED 014000 bisacsh MED 022000 bisacsh MED 112000 bisacsh MED 045000 bisacsh 616.462061 23 Sonia, Thundiparambil Azeez, author. Oral delivery of insulin / [electronic resource] Thundiparambil Azeez Sonia, Chandra P. Sharma. Oxford : Woodhead Publishing, 2014. 1 online resource. text txt rdacontent computer c rdamedia online resource cr rdacarrier Woodhead publishing series in biomedicine ; number 41 CIP data; item not viewed. Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Machine generated contents note: 1. Diabetes mellitus -- an overview -- 1.1. Diabetes mellitus -- an introduction -- 1.2. Glucose homeostasis -- 1.3. Types of diabetes -- 1.4. Symptoms of diabetes -- 1.5. Complications of diabetes -- 1.6. Diagnosis of diabetes mellitus -- 1.7. Therapy for diabetes -- 1.8. Non-insulin treatment options of type 1 diabetes -- 1.9. Treatment options of type 2 diabetes -- 1.10. Conclusion -- 1.11. References -- 2. Routes of administration of insulin -- 2.1. Current approach for the delivery of insulin -- 2.2. Routes of administration of insulin -- 2.3. Conclusion -- 2.4. References -- 3. Oral insulin delivery -- challenges and strategies -- 3.1. Oral delivery of insulin -- 3.2. Barriers to oral delivery of insulin -- 3.3. Strategies and alternatives to improve oral insulin delivery -- 3.4. Conclusion -- 3.5. References -- 4. Experimental techniques involved in the development of oral Insulin carriers -- 4.1. Introduction -- 4.2. Polymeric nanoparticles -- 4.3. Physicochemical characterization of nanoparticles -- 4.4. Biological evaluation -- 4.5. In vitro method for assessing drug permeability -- 4.6. In vivo study of oral insulin -- 4.7. Biodistribution studies -- 4.8. Conclusion -- 4.9. References -- 5. Lipids and inorganic nanoparticles in oral insulin delivery -- 5.1. Lipid-based systems for oral delivery of insulin -- 5.2. Liposomes -- 5.3. Solid lipid nanoparticles -- 5.4. Nanostructured lipid carriers -- 5.5. Niosomes -- 5.6. Archaeosomes -- 5.7. Cubic nanoparticles (cubosomes) -- 5.8. Aquasomes -- 5.9. Inorganic nanoparticles as carriers for oral insulin delivery -- 5.10. Conclusion -- 5.11. References -- 6. Polymers in oral insulin delivery -- 6.1. Introduction -- 6.2. Characteristics of an ideal oral insulin carrier -- 6.3. Polymers in oral insulin delivery -- 6.4. Natural polymers -- 6.5. Synthetic polymers -- 6.6. Conclusion -- 6.7. References -- 7. Summary and future perspectives for oral insulin delivery -- 7.1. Introduction -- 7.2. Technologies developed for clinical applications of oral insulin delivery -- 7.3. Conclusions and future perspectives -- 7.4. References. Includes bibliographical references and index. Insulin Therapeutic use Administration. Diabetes Oral therapy. HEALTH & FITNESS Diseases General. bisacsh MEDICAL Clinical Medicine. bisacsh MEDICAL Diseases. bisacsh MEDICAL Evidence-Based Medicine. bisacsh MEDICAL Internal Medicine. bisacsh Diabetes Oral therapy. fast (OCoLC)fst00892178 Insulin Therapeutic use Administration. fast (OCoLC)fst00974518 Insulin administration & dosage. (DNLM)D007328Q000008 Administration, Oral. (DNLM)D000284 Drug Delivery Systems. (DNLM)D016503 Electronic books. Electronic book. Electronic books. lcgft Sharma, Chandra P., author. Print version: Sharma, C.P. Oral delivery of insulin. Cambridge : Woodhead, 2014 9781907568473 (DLC) 2014950424 (OCoLC)876802531 Woodhead Publishing series in biomedicine ; no. 41. 2050-0289 ScienceDirect http://www.sciencedirect.com/science/book/9781907568473 246954 246954