Lai, Yurong. creator text bibliography Electronic books. enk Oxford Elsevier Science 2013 monographic eng

electronic resource

1 online resource (xxiii, 734 pages) : illustrations. Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies. Yurong Lai. Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery. Includes bibliographical references and index. Biopharmaceutics Drug development Drugs Design MEDICAL Pharmacology Biopharmaceutics Drug development Drugs Design RM301.25 615.19 Lai, Yurong. Burlington : Elsevier Science, �2013 9781908818287 190881828X http://www.sciencedirect.com/science/book/9781907568213 http://www.sciencedirect.com/science/book/9781907568213 EBLCP 140830 20190328114808.0 ocn889675352 eng