03028cam a2200481Ki 4500 ocn889675352 OCoLC 20190328114808.0 m o d cr cnu---unuuu 140830s2013 enka ob 001 0 eng d EBLCP eng pn EBLCP OCLCO N$T GZM MYG UIU OCLCF OPELS OCLCQ U3W D6H 9781908818287 (electronic bk.) 190881828X (electronic bk.) 9781907568213 (print) (OCoLC)889675352 RM301.25 MED 071000 bisacsh 615.19 Lai, Yurong. Transporters in drug discovery and development : detailed concepts and best practice / [electronic resource] Yurong Lai. Oxford : Elsevier Science, 2013. 1 online resource (xxiii, 734 pages) : illustrations. text txt rdacontent computer c rdamedia online resource cr rdacarrier Woodhead Publishing Series in Biomedicine Includes bibliographical references and index. Print version of record. Membrane transporters and the diseases corresponding to functional defects -- P-glycoprotein (P-gp/MDR1)/ABCB1 -- Multidrug resistanceassociated protein 2 (MRP2/ABCC2) -- Breast cancer resistance protein (BCRP)/ABCG2 -- The bile salt export pump (BSEP/ABCB11) -- Organic aniontransporting polypeptides (OATPs/SLCOs) -- Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs) -- Drug transporters in drug discovery and development -- 9 Transporter study methodologies. Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery. Biopharmaceutics. Drug development. Drugs Design. MEDICAL Pharmacology. bisacsh Biopharmaceutics. fast (OCoLC)fst00832650 Drug development. fast (OCoLC)fst00898670 Drugs Design. fast (OCoLC)fst00898790 Electronic books. Print version: Lai, Yurong. Transporters in Drug Discovery and Development : Detailed Concepts and Best Practice. Burlington : Elsevier Science, �2013 9781907568213 Woodhead Publishing series in biomedicine. ScienceDirect http://www.sciencedirect.com/science/book/9781907568213 246950 246950