04431cam a2200481Mi 4500001001300000003000600013005001700019006001900036007001500055008004100070040012000111066000700231019001400238020003600252020003300288020001800321035003900339050001000378072002500388082001000413245011200423260004300535300002300578336002600601337002600627338003600653490005700689588002600746505104100772520042501813650003402238650004202272650006002314655002202374700002202396776013902418830005802557856007502615856007902690880058602769880057503355999001903930ocn913618259OCoLC20190328114808.0m     o  d        cr cn|||||||||140719s2014    vtu     o     000 0 eng d  aUABbengepncUABdOCLCOdEBLCPdOPELSdN$TdNOCdYDXCPdOCLCFdDEBSZdUIUdOCLCQdESUdOCLCQdU3WdD6HdYOUdDEBBG  c(S  a884014639  a9780124171916q(electronic bk.)  a0124171915q(electronic bk.)  z9780124171855  a(OCoLC)913618259z(OCoLC)884014639 4aQD262 7aSCIx0130402bisacsh04a547.200aStrategies and tactics in organic synthesis : Vol. 10 / h[electronic resource]cedited by Michael Harmata.  aBurlington :bElsevier Science,c2014.  a1 online resource.  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier1 aStrategies and Tactics in Organic Synthesis ;vv. 100 aPrint version record.0 aSubstrate-Directed Heck-Matsuda Arylations; ( -- )-Berkelic Acid: Lessons Learned From Our Investigations on a Scalable Total Synthesis; The Mysterious Case of the Kingianins; Total Synthesis of Chinensiolide B: An Exercise in Functional Group Selectivity with the Help of a Fortuitous Side Product and a Good Nose; Syntheses of the Bisindole Alkaloids of the Genera Borreria and Flindersia; Synthesis of (�)-Amathaspiramide F: Stereochemical Switch of a [2,3]-Stevens ; Oxabicyclic Building Blocks as Key Intermediates in the Synthesis of the Natural Products ( -- )-Platensimycin and (+)-Frondosin A; Structure Inspires a New Method That Delivers the Synthesis of Natural Products and Analogs in the Pederin Family; Gliocladin C: The Development and Application of a Pyrroloindoline-Indole Radical Coupling Reaction; Studies in the Synthesis of Biaryl Natural Products: The 6,6'-Binaphthopyranones; Sleepless Nights: The Total Synthesis of the Anticancer Australian Rainforest Polyketide EBC-23; Total Synthesis of the Crinipellins.  aA classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. 0aOrganic compoundsxSynthesis. 7aSCIENCExChemistryxOrganic.2bisacsh 7aOrganic compoundsxSynthesis.2fast0(OCoLC)fst01047668 4aElectronic books.1 aHarmata, Michael.08iPrint version:aHarmata, Michael.tStrategies and Tactics in Organic Synthesis.dBurlington : Elsevier Science, �2014z9780124171855 0aStrategies and Tactics in Organic Synthesis ;vv. 10.403ScienceDirectuhttp://www.sciencedirect.com/science/book/9780124171855403ScienceDirectuhttp://www.sciencedirect.com/science/bookseries/18746004/108 6505-00a7. Synthesis of Kingianin A8. ``Go Fish� � -Pursuit of the Intermolecular RCDA Approach; 9. Formal Synthesis of Kingianin A and Synthesis of Kingianins D, F, H, and J; 10. NCI 60 Test Results for Kingianins A (NSC#D-768505/1) and H (NSC#D-768506/1); 11. Reconsidering the Biosynthesis; 12. Conclusions; Acknowledgments; References; Chapter 4: Total Synthesis of Chinensiolide B: An Exercise in Functional Group Selectivity with the Help of a Fortuitous Side product and a good nose; 1. Introduction; 1.1. Chinensiolide and Other (Sa(B-Methylene (Sd(B-Lactones in Nature8 6505-00a1.2. Traditional Methods for the Synthesis of (Sa(B-Methylene (Sd(B-Lactones1.3. Use of 2-Alkoxycarbonyl Allylboronates to Access (Sa(B-Methylene (Sd(B-Lactones; 2. Model Studies and Retrosynthetic Analysis; 2.1. Retrosynthetic Analysis; 2.2. Model Studies; 3. Design and Synthesis of the Key Allylboronate; 3.1. Selection of the Protecting Group; 3.2. Synthesis of Disubstituted Allylboronate 7; 4. Synthesis of the Cyclopentyl Aldehyde Substrate; 4.1. Literature Precedent; 4.2. Preparation of Aldehyde 6; 5. Critical Moment-The Key Aldehyde Allylboration Step  c246933d246933