05811cam a2200601Ka 4500001001300000003000600013005001700019006001900036007001500055008004100070040021400111016001800325016001800343019004700361020003600408020003300444020002600477020001500503035009300518050001200611060001200623072002500635072002500660072002500685082001600710100003400726245015300760264003700913300005500950336002601005336003301031337002601064338003601090504005101126588005001177520056801227505057801795505059902373505053202972505058303504505059604087650002004683650003204703650004604735650004604781650004604827650004204873650002704915655002204942776015104964856007505115999001905190ocn878860307OCoLC20190328114807.0m     o  d        cr |||||||||||140414s2014    enka    ob    001 0 eng d  aUKMGBbengepncUKMGBdOCLCOdOPELSdN$TdYDXCPdGZMdOCLCFdTEFODdCDXdOCLCQdTEFODdEBLCPdIDEBKdE7BdDEBSZdDHAdTEFODdOCLCQdYDXdVGMdMERUCdOCLCQdOCLCOdOCLCAdU3WdOCLCOdD6HdCHVBKdOTZdOCLCQdTKN7 a0166982082Uk7 a0166973682Uk  a880059521a961200654a961409203a965724430  a9780124105102q(electronic bk.)  a0124105106q(electronic bk.)  z9780124104716q(hbk.)  z0124104711  a(OCoLC)878860307z(OCoLC)880059521z(OCoLC)961200654z(OCoLC)961409203z(OCoLC)965724430 4aQH324.2 4aQU 26.5 7aNATx0270002bisacsh 7aSCIx0080002bisacsh 7aSCIx0860002bisacsh04a570.2852231 aChoudhuri, Supratim,eauthor.10aBioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools / h[electronic resource]cby Supratim Choudhuri. 1aLondon :bAcademic Press,c2014.  a1 online resource (xi, 225 pages) :billustrations  atextbtxt2rdacontent  astill imagebsti2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  aIncludes bibliographical references and index.0 aPDF (ScienceDirect, viewed on July 18, 2014).  aBioinformatics for Beginners provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis, and demonstrates with examples targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis and points to many further study options.0 aFront Cover; Bioinformatics for beginners; Copyright Page; Contents; Preface; Acknowledgment; 1 Fundamentals of Genes and Genomes; 1.1 Biological Macromolecules, Genomics, and Bioinformatics; 1.2 DNA as the Universal Genetic Material; 1.3 DNA Double Helix; 1.3.1 Structural Units of DNA; 1.3.2 Linkage between Nucleotides; 1.3.3 Base-Pairing Rules, Double Helix, and Triple Helix; 1.3.4 Single-Stranded DNA; 1.3.5 Base Sequence and the Genetic Code; 1.4 Conformations of DNA; 1.5 Typical Eukaryotic Gene Structure; 1.5.1 Transcribed Region; 1.5.1.1 Intron-Splicing Signals.8 a1.5.1.2 Effect of Intron Phase on Alternative Splicing1.5.1.3 Evolution of Introns; 1.5.2 52 Flanking Region of Transcribed Genes; 1.5.3 32 Flanking Region of Transcribed Genes; 1.6 Mutations in the DNA Sequence; 1.7 Some Features of RNA; 1.7.1 Instability of mRNA; 1.7.2 52 and 32 Untranslated Regions of mRNA; 1.7.3 Secondary Structures in RNA; 1.8 Coding Versus Noncoding RNA; 1.8.1 Small Noncoding RNA, Long Noncoding RNA, Competing Endogenous RNA, and Circular RNA; 1.9 Protein Structure and Function; 1.9.1 Configuration and Chirality of Amino Acids; 1.9.2 Ionic Character of Amino Acids.8 a1.9.3 Relationship between Protein Function and the Location of Amino Acids in the Polypeptide Chain1.9.4 Linkage between Amino Acids-The Peptide Bond; 1.9.5 Four Levels of Protein Structure; 1.9.6 Acidic and Basic Proteins; 1.9.7 Nonstandard Amino Acids in Polypeptide Chains; 1.10 Genome Structure and Organization; 1.10.1 The Structure of a Representative Genome-The Human Genome; 1.10.2 Functional Sequence Elements in the Genome; 1.10.2.1 Promoters; 1.10.2.2 Enhancers; 1.10.2.3 Locus Control Regions; 1.10.2.4 Insulators.8 a1.10.3 Epigenetic Modifications of the Genome Can Edit the Language Written in the DNA Sequence and Add an Extra Layer of C ... 1.10.3.1 Histone Code; 1.10.3.2 The Dynamics of Epigenetic Changes; 1.10.4 Lessons Learned from the Second Phase of the ENCODE Project about the DNA Elements in the Human Genome and its Epige ... ; References; 2 Fundamentals of Molecular Evolution; 2.1 Bioinformatics, Molecular Evolution, and Phylogenetics; 2.2 Biological Evolution and Basic Premises of Darwinism; 2.2.1 First Experimental Demonstration of Evolutionary Principles in the Test Tube.8 a2.3 Molecular Basis of Heritable Genetic Variations-The Raw Materials for Evolution2.3.1 Molecular Basis of Mutation; 2.3.2 Recombination and Generation of Genetic Diversity; 2.3.3 Gene Flow and Introduction of Genetic Diversity; 2.3.4 Origin of New Genes, Creation of Genetic Diversity and Genome Evolution; 2.3.4.1 Origin of New Genes from Coding Sequences (Pre-existing Genes); 2.3.4.1.a Gene Duplication and the 2R Hypothesis; 2.3.4.1.b Exon Shuffling; 2.3.4.1.c Gene Fusion and Fission; 2.3.4.1.d Horizontal Gene Transfer; 2.3.4.2 Origin (de Novo) of New Genes from Noncoding Sequences. 0aBioinformatics. 7aNATURExReference.2bisacsh 7aSCIENCExLife SciencesxBiology.2bisacsh 7aSCIENCExLife SciencesxGeneral.2bisacsh 7aBioinformatics.2fast0(OCoLC)fst00832181 7aBioinformatik2gnd0(DE-588)4611085-9 2aComputational Biology. 4aElectronic books.08iPrint version:tBioinformatics for beginners.dLondon ; Waltham, MA : Academic Press is an imprint of Elsevier, 2014z0124104711w(OCoLC)875239434403ScienceDirectuhttp://www.sciencedirect.com/science/book/9780124104716  c246906d246906