02284nam a22003138a 4500001001600000003000700016005001700023006001900040007001500059008004100074020002600115020002900141040002400170082001700194245013700211264005200348300005900400336002600459337002600485338003600511500007300547520109300620700004201713700004601755700004401801776003501845856007101880999001901951CR9780511976117UkCbUP20180107143414.0m|||||o||d||||||||cr||||||||||||101011s2011||||enk     s     ||1 0|eng|d  a9780511976117 (ebook)  z9780521887212 (hardback)  aUkCbUPcUkCbUPerda00a616.99/422200aCancer Metastasis :bBiologic Basis and Therapeutics / [electronic resource]cEdited by David Lyden, Danny R.  Welch, Bethan Psaila. 1aCambridge :bCambridge University Press,c2011.  a1 online resource (660 pages) :bdigital, PDF file(s).  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  aTitle from publisher's bibliographic system (viewed on 09 Oct 2015).  aMetastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.1 aLyden, David,eeditor of compilation.1 aWelch, Danny R. ,eeditor of compilation.1 aPsaila, Bethan,eeditor of compilation.08iPrint version: z978052188721240uhttp://dx.doi.org/10.1017/CBO9780511976117zCambridge Books Online  c236633d236633