02215nam a22003618a 4500 CR9780511973888 UkCbUP 20180107143414.0 m|||||o||d|||||||| cr|||||||||||| 101011s2011||||enk s ||1 0|eng|d 9780511973888 (ebook) 9780521517713 (hardback) 9780521734448 (paperback) UkCbUP UkCbUP rda RS419.5 .Z43 2011 615/.19 22 Zhang, Xiaohua Douglas, author. Optimal High-Throughput Screening : Practical Experimental Design and Data Analysis for Genome-Scale RNAi Research / [electronic resource] Xiaohua Douglas Zhang. Cambridge : Cambridge University Press, 2011. 1 online resource (232 pages) : digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier Title from publisher's bibliographic system (viewed on 09 Oct 2015). This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments. High throughput screening (Drug development) Small interfering RNA Experimental design RNA Interference Print version: 9780521517713 http://dx.doi.org/10.1017/CBO9780511973888 Cambridge Books Online 236616 236616