02131nam a22003378a 4500 CR9780511736179 UkCbUP 20180107143412.0 m|||||o||d|||||||| cr|||||||||||| 100329s2011||||enk s ||1 0|eng|d 9780511736179 (ebook) 9781107001596 (hardback) UkCbUP UkCbUP rda QH324.2 .P352 2011 572.80285 22 Palsson, Bernhard Ø., author. Systems Biology: Simulation of Dynamic Network States / [electronic resource] Bernhard Ø. Palsson. Cambridge : Cambridge University Press, 2011. 1 online resource (332 pages) : digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier Title from publisher's bibliographic system (viewed on 09 Oct 2015). Biophysical models have been used in biology for decades, but they have been limited in scope and size. In this book, Bernhard Ø. Palsson shows how network reconstructions that are based on genomic and bibliomic data, and take the form of established stoichiometric matrices, can be converted into dynamic models using metabolomic and fluxomic data. The Mass Action Stoichiometric Simulation (MASS) procedure can be used for any cellular process for which data is available and allows a scalable step-by-step approach to the practical construction of network models. Specifically, it can treat integrated processes that need explicit accounting of small molecules and protein, which allows simulation at the molecular level. The material has been class-tested by the author at both the undergraduate and graduate level. All computations in the text are available online in MATLAB and MATHEMATICA® workbooks, allowing hands-on practice with the material. Computational biology Genomics Bioinformatics Print version: 9781107001596 http://dx.doi.org/10.1017/CBO9780511736179 Cambridge Books Online 236509 236509