02153nam a22003498a 4500001001600000003000700016005001700023006001900040007001500059008004100074020002600115020002900141040002400170050002700194082001700221245011800238264005200356300005900408336002600467337002600493338003600519500007300555520090900628650001501537650001901552650003301571650002601604700004501630700004601675776003501721856004701756CR9780511760334UkCbUP20171022140753.0m|||||o||d||||||||cr||||||||||||100506s2010||||enk     s     ||1 0|eng|d  a9780511760334 (ebook)  z9780521112086 (hardback)  aUkCbUPcUkCbUPerda00aQP552.G16 bG1747 201100a572/.69622200aG Protein-Coupled Receptors :bStructure, Signaling, and Physiology /cEdited by Sandra Siehler, Graeme Milligan. 1aCambridge :bCambridge University Press,c2010.  a1 online resource (446 pages) :bdigital, PDF file(s).  atextbtxt2rdacontent  acomputerbc2rdamedia  aonline resourcebcr2rdacarrier  aTitle from publisher's bibliographic system (viewed on 09 Oct 2015).  aProvides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field. 0aG proteins 0aCell receptors 0aCellular signal transduction 0aDrug Delivery Systems1 aSiehler, Sandra,eeditor of compilation.1 aMilligan, Graeme,eeditor of compilation.08iPrint version: z978052111208640uhttp://dx.doi.org/10.1017/CBO9780511760334