05324cam a2200637 i 4500 ocn929332125 OCoLC 20171024082406.0 m o d cr ||||||||||| 151113s2016 enk ob 001 0 eng 2015044701 9781118760338 (ePub) 1118760336 (ePub) 9781118760352 (Adobe PDF) 1118760352 (Adobe PDF) 9781118760376 (hardback) 9781118760369 1118760360 GBVCP 855500115 DEBBG BV043738151 (OCoLC)929332125 (OCoLC)935254348 DLC eng rda DLC N$T YDXCP IDEBK DG1 EBLCP DEBBG KSU CCO pcc MAIN QP356.4 MED 075000 bisacsh SCI 036000 bisacsh 612.8 23 SCI089000 bisacsh Molecular neuroendocrinology : from genome to physiology / [edited by] David Murphy, Harold Gainer. [electronic resource] Chichester, West Sussex ; Hoboken, NJ : Wiley Blackwell, 2016. 1 online resource. text rdacontent computer rdamedia online resource rdacarrier Wiley-INF Masterclass in Neuroendocrinology Series Includes bibliographical references and index. Title Page; Table of Contents; List of Contributors; Series Preface; About the Companion Website; Introduction; Part A: Genome and Genome Expression; CHAPTER 1: Evolutionary Aspects of Physiological Function and Molecular Diversity of the Oxytocin/Vasopressin Signaling System; 1.1 Evolution of peptidergic signaling; 1.2 The discovery of neuropeptide signaling components in the era of genomics; 1.3 Evolutionary aspects of OXT/AVP diversity; 1.4 Physiology of OXT and AVP signaling: from worm to man; 1.5 Perspectives; Acknowledgments; References; CHAPTER 2: The Neuroendocrine Genome: 2.1 The discovery of neuropeptides2.2 Characteristics of neuropeptides; 2.3 Neuropeptide genes in the genome; 2.4 Perspectives; Acknowledgments; References; Further reading; CHAPTER 3: Transcriptome Dynamics; 3.1 Approaching transcriptome dynamics; 3.2 Transcriptome dynamics in neuroendocrine systems; 3.3 Transcriptome dynamics in the pineal gland: lessons from different approaches; 3.4 SN-NICHD transcriptome profiling web page; 3.5 Perspectives; References; CHAPTER 4: New Players in the Neuroendocrine System:; 4.1 Non-coding RNA contribution to gene regulation 4.2 Central role of the hypothalamus as a neuroendocrine organ4.3 The pituitary gland and its central control of the peripheral endocrine system; 4.4 The pineal gland -- a connector between external environment and internal homeostasis; 4.5 Perspectives; References; CHAPTER 5: Transcription Factors Regulating Neuroendocrine Development, Function, and Oncogenesis; 5.1 The key players in transcriptional regulation; 5.2 Classes of neuroendocrine-associated TFs; 5.3 REST: a zinc finger TF with complex regulation and diverse function; 5.4 Cooperation of TFs in neuroendocrine phenotype and function 5.5 PerspectivesReferences; CHAPTER 6: Epigenetics; 6.1 Introduction; 6.2 Early life adversity shapes the HPA axis; 6.3 Epigenetic mechanisms: changes in the regulation of gene activity and expression that are not dependent on gene sequence; 6.4 Methods of epigenetic analysis; 6.5 Alterations in epigenetic processes; 6.6 The epigenome and early life adversity; 6.7 Perspectives; References; Further reading; Part B: Proteins, Posttranslational Mechanisms, and Receptors; CHAPTER 7: Proteome and Peptidome Dynamics; 7.1 Introduction; 7.2 Classic neuropeptides and proteins in the RSP 7.3 Techniques used to study the rate of peptide biosynthesis7.4 Dynamics of intracellular proteins and peptides; 7.5 Perspectives; References; CHAPTER 8: Neuropeptidomics; 8.1 Neuropeptides -- one gene, multiple products; 8.2 Mining the neuropeptidome 21st-century style using mass spectrometry-based 'omics approaches; 8.3 What do all these peptides do? Follow-up functional studies; 8.4 Perspectives; Acknowledgments; References; Further reading; CHAPTER 9: Posttranslational Processing of Secretory Proteins; 9.1 Posttranslational modifications of secretory proteins "Discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification"-- Provided by publisher. Description based on print version record and CIP data provided by publisher. Neuroendocrinology Molecular apects. SCIENCE / Life Sciences / Neuroscience. bisacsh Electronic books. Electronic books. Murphy, David, 1957- editor. Gainer, Harold, editor. Print version: Molecular neuroendocrinology Chichester, West Sussex ; Hoboken, NJ : John Wiley & Sons, Inc., 2016 9781118760376 (DLC) 2015031889 Wiley-INF Masterclass in Neuroendocrinology Series. http://onlinelibrary.wiley.com/book/10.1002/9781118760369 Wiley Online Library ddc BK 208238 208238