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  <titleInfo>
    <title>Attrition in the pharmaceutical industry : reasons, implications, and pathways forward</title>
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  <name type="personal">
    <namePart>Alex, Alexander A.</namePart>
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  <name type="personal">
    <namePart>Harris, C. John</namePart>
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  <name type="personal">
    <namePart>Smith, Dennis A.</namePart>
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  <tableOfContents>Attrition in drug discovery and development / Scott Boyer, Clive Brealey and Andrew M. Davis -- Compound attrition at the pre-clinical phase / Cornelis E.C.A. Hop -- Attrition in phase I / Dennis A. Smith and Thomas A. Baillie -- Compound attrition in phase II/III / Alexander Alex, C. John Harris, Wilma W. Keighley and Dennis A. Smith -- Post-marketing attrition / Dennis A. Smith -- Influence of the regulatory environment on attrition / Robert T. Clay -- Experimental screening strategies to reduce attrition risk / Marie-Claire Peakman, Matthew Troutman, Rose Gonzales and Anne Schmidt -- Medicinal chemistry strategies to prevent compound attrition / J. Richard Morphy -- Influence of phenotypic and target-based screening strategies on compound attrition and project choice / Andrew Bell, Wolfgang Fecke and Christine Williams -- In silico approaches to address compound attrition / Peter Gedeck, Christian Kramer, Richard Lewis -- Current and future strategies for improving drug discovery efficiency / Peter Mbugua Njogu and Kelly Chibale -- Impact of investment strategies, organizational structure and corporate environment on attrition, and future investment strategies to reduce attrition / Geoff Lawton.</tableOfContents>
  <note type="statement of responsibility">edited by Alexander A. Alex, C. John Harris, Dennis A. Smith.</note>
  <note>Includes index.</note>
  <subject authority="lcsh">
    <topic>Pharmaceutical industry</topic>
    <topic>Management</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Pharmaceutical industry</topic>
    <topic>Capital productivity</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Industrial efficiency</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Drug development</topic>
  </subject>
  <subject authority="fast">
    <topic>Drug development</topic>
  </subject>
  <subject authority="fast">
    <topic>Industrial efficiency</topic>
  </subject>
  <subject authority="fast">
    <topic>Pharmaceutical industry</topic>
    <topic>Capital productivity</topic>
  </subject>
  <subject authority="fast">
    <topic>Pharmaceutical industry</topic>
    <topic>Management</topic>
  </subject>
  <subject authority="bisacsh">
    <topic>MEDICAL / Pharmacology</topic>
  </subject>
  <classification authority="lcc">HD9665.5</classification>
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      <publisher>Hoboken, New Jersey : John Wiley &amp; Sons, 2015</publisher>
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