05638cam a2200685 i 4500 ocn911200069 OCoLC 20171024104724.0 m o d cr ||||||||||| 150617s2015 nju ob 001 0 eng 2015024112 9781119016724 (pdf) 111901672X (pdf) 9781119017103 (epub) 1119017106 (epub) 9781118709238 (cloth) 9781119017127 1119017122 1118709233 (cloth) 9781118709238 (cloth) AU@ 000054950152 CHVBK 357601203 CHBIS 010598228 GBVCP 838919863 DEBBG BV043397894 (OCoLC)911200069 DLC eng rda DLC OCLCF N$T IDEBK YDXCP DG1 EBLCP CDX COO DEBBG KSU RECBK CCO pcc MAIN RB147.5 SCI 007000 bisacsh 572.8/69 23 The functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria / edited by Valentin K. Gribkoff, Elizabeth A. Jonas, J. Marie Hardwick. [electronic resource] 1511 Hoboken, New Jersey : John Wiley & Sons, 2015. 1 online resource. text rdacontent computer rdamedia online resource rdacarrier Wiley series on neuropharmacology Includes bibliographical references and index. Mitochondrial permeability transition : look from a different angle / N. Brustovetsky -- The mitochondrial permeability transition pore, the c-subunit of the F1Fo ATP synthase, cellular development and synaptic efficiency / E.A. Jonas, G.A. Porter, Jr., G. Beutner, N. Mnatsakanyan and K.A. Alavian -- Mitochondrial channels in neurodegeneration / P.M. Peixoto, K.W. Kinnally and Evgeny Pavlov -- Mitochondrial Ca2+ transport in the control of neuronal functions : molecular and cellular mechanisms / Y.M. Usachev -- AMP-activated protein kinase (AMPK) as a cellular energy sensor and therapeutic target for neuroprotection / P. Weisova, S. Pfeiffer and J.H.M. Prehn -- HDAC6 : a molecule with multiple functions in neurodegenerative diseases / Y. Yan and R. Jiao -- Neuronal mitochondrial transport / A.L. Knight, Y. Chen, T. Sun and Z.-H. Sheng -- Mitochondria in control of hypothalamic metabolic circuits / C.M. Nasrallah and T.L. Horvath -- Mitochondria anchored at the synapse / G.A. Spirou, D. Jackson and G.A. Perkins -- Neuronal mitochondria are different : relevance to neurodegenerative disease / S.B. Berman and J.M. Hardwick -- PINK1 as a sensor for mitochondrial function : dual roles / E.K. Steer, M.K. Dail and C.T. Chu -- A get-together to tear it apart : the mitochondrion meets the cellular turnover machinery / G.-L. McLelland and E.A. Fon -- Mitochondrial involvement in neurodegenerative dementia / L. Bonanni, V. Frazzini, A. Thomas and M. Onofrj -- Neuronal mitochondria as a target for the discovery and development of new therapeutics / V.K. Gribkoff -- Mitochondria as a therapeutic target for Alzheimer's disease / C.H.-L. Hung, S.S.-Y. Chung, S.M.-Y. Lee and R.C.-C. Chang -- Mitochondria in Parkinson disease / G. Arena and E.M. Valente -- Therapeutic targeting of neuronal mitochondria in brain injury / H.M. Yonutas, E.D. Hall and P.G. Sullivan -- The use of fibroblasts from patients with inherited mitochondrial disorders for pathomechanistic studies and evaluation of therapies / D. Soiferman and A. Saada. This book presents advances in the field of neuronal mitochondria - functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases.- Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death- Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments- Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field- Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders. Description based on print version record and CIP data provided by publisher. Mitochondrial pathology. Mitochondria Formation. Nervous system Diseases Treatment. Mitochondria Formation. fast (OCoLC)fst01024017 Mitochondrial pathology. fast (OCoLC)fst01024022 Nervous system Diseases Treatment. fast (OCoLC)fst01036124 SCIENCE / Life Sciences / Biochemistry bisacsh Electronic books. Gribkoff, Valentin K., editor. Jonas, Elizabeth A., editor. Hardwick, J. Marie, editor. Print version: Functions, disease-related dysfunctions, and therapeutic targeting of neuronal mitochondria Hoboken, New Jersey : John Wiley & Sons, 2015 9781118709238 (DLC) 2015020365 http://onlinelibrary.wiley.com/book/10.1002/9781119017127 Wiley Online Library ddc BK 208090 208090