03683cam a2200721Ii 4500 ocn905991359 OCoLC 20171025084459.0 m o d cr cnu---unuuu 150328s2015 gw ob 001 0 eng d 9783527673049 electronic bk. 3527673040 electronic bk. 9783527673025 electronic bk. 3527673024 electronic bk. 9783527673056 electronic bk. 3527673059 electronic bk. 9783527673032 electronic bk. 3527673032 electronic bk. 9783527335824 (print ; alk. paper) 352733582X (print ; alk. paper) 10.1002/9783527673025 doi GBVCP 83642624X DEBBG BV043397671 (OCoLC)905991359 (OCoLC)910983561 EBLCP eng rda pn EBLCP OCLCO RECBK OCLCQ YDXCP OCLCO N$T IDEBK DG1 OCLCF COO N$T QGK DEBBG KSU MAIN RM301.25 .T44 2015eb W1 ME9613h v.65 2015 QV 745 MED 071000 bisacsh 615.19 23 Thermodynamics and kinetics of drug binding / edited by György M. Keserü and David C. Swinney. [electronic resource] Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, [2015] 1 online resource (xxiii, 334 pages) : illustrations (some color) text txt rdacontent computer c rdamedia online resource cr rdacarrier Methods and principles in medicinal chemistry ; volume 65 Includes bibliographical references and index. "This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors."-- Publisher's info. Description based on print version record. Drug development. Binding sites (Biochemistry) Thermodynamics. Pharmacokinetics. MEDICAL / Pharmacology bisacsh Binding sites (Biochemistry) Thermodynamics. fast (OCoLC)fst00831877 Drug development. fast (OCoLC)fst00898670 Pharmacokinetics. fast (OCoLC)fst01060250 Drug Discovery. Receptors, Drug. Ligands. Thermodynamics. Pharmacokinetics. Electronic books. Electronic books. Keserü, G. M., editor. Swinney, David Carl, editor. Print version: Thermodynamics and kinetics of drug binding 9783527335824 (OCoLC)910103973 Methods and principles in medicinal chemistry ; v. 65. http://onlinelibrary.wiley.com/book/10.1002/9783527673025 Wiley Online Library ddc BK 207966 207966