05648cam a2200697Ia 4500 ocn904518353 OCoLC 20171025092907.0 m o d cr cnu---unuuu 150307s2015 gw ob 001 0 eng d 9783527673643 (electronic bk.) 3527673644 (electronic bk.) 9783527673674 (electronic bk.) 3527673679 (electronic bk.) 9783527673667 3527673660 9783527335114 3527335110 CHDSB 006359936 CHVBK 332136523 DEBBG BV042792550 DEBBG BV043397595 (OCoLC)904518353 (OCoLC)909907512 (OCoLC)953987850 (OCoLC)960203676 (OCoLC)961625844 (OCoLC)962626284 EBLCP eng pn EBLCP OCLCO RECBK N$T YDXCP IDEBK CDX DG1 E7B OCLCF COO DEBBG OCLCQ OHI MAIN RS420 MED 071000 bisacsh 615.19 23 Antitargets and drug safety / edited by Laszlo Urban, Vinod F. Patel and Roy J. Vaz. [electronic resource] Weinheim : Wiley-VCH, 2015. 1 online resource (1266 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Methods and principles in medicinal chemistry ; v. 66 Includes bibliographical references and index. General Concept for Target-based Safety Assessment. Side Effects of Marketed Drugs: The Utility and Pitfalls of Pharmacovigilance / Steven Whitebread, Mateusz Maciejewski, Alexander Fekete, Eugen Lounkine, László Urbán -- Prediction of Drug Side Effects / Michael J Keiser -- Translational Value of Preclinical Safety Assessment: System Organ Class (SOC) Representation of Off-Targets / Mateusz Maciejewski, Eugen Lounkine, Andreas Hartmann, Steven Whitebread, László Urbán -- Pathological Conditions Associated with the Disturbance of the 5-HT System / Daniel Hoyer -- Hepatic Side Effects. Drug-Induced Liver Injury: Clinical and Diagnostic Aspects / John R Senior -- Mechanistic Safety Biomarkers for Drug-Induced Liver Injury / Daniel J Antoine -- Models for the Prediction of Drug-Induced Liver Injury in Lead Discovery / Frederic Moulin, Oliver Flint -- Transporters in the Liver / Bruno Stieger, Gerd A Kullak-Ublick -- Mechanistic Modeling of Drug-Induced Liver Injury (DILI) / Kyunghee Yang, Jeffrey L Woodhead, Lisl K Shoda, Yuching Yang, Paul B Watkins, Kim LR Brouwer, Brett A Howell, Scott Q Siler -- Cardiovascular Side Effects. Functional Cardiac Safety Evaluation of Novel Therapeutics / Jean-Pierre Valentin, Brian Guth, Robert L Hamlin, Pierre Lainée, Dusty Sarazan, Matt Skinner -- Safety Aspects of the Ca1.2 Channel / Berengere Dumotier, Martin Traebert -- Cardiac Sodium Current (Na1.5) / Gary Gintant -- Circulating Biomarkers for Drug-Induced Cardiotoxicity: Reverse Translation from Patients to Nonclinical Species / Gül Erdemli, Haisong Ju, Sarita Pereira -- The Mechanistic Basis of hERG Blockade and the Proarrhythmic Effects Thereof / Robert A Pearlstein, K Andrew MacCannell, Qi-Ying Hu, Ramy Farid, José S Duca -- Kinase Antitargets. Introduction to Kinase Antitargets / Mark C Munson -- Clinical and Nonclinical Adverse Effects of Kinase Inhibitors / Douglas A Keller, Richard J Brennan, Karen L Leach -- Cardiac Side Effects Associated with Kinase Proteins and Their Signaling Pathways / Roy J Vaz, Vinod F Patel -- Case Studies: Selective Inhibitors of Protein Kinases : Exploiting Demure Features / Ellen R Laird -- Examples of Clinical Translation. Torcetrapib and Dalcetrapib Safety: Relevance of Preclinical and Models / Eric J Niesor, Andrea Greiter-Wilke, Lutz Müller -- Targets Associated with Drug-Related Suicidal Ideation and Behavior / Andreas Hartmann, Steven Whitebread, Jacques Hamon, Alexander Fekete, Christian Trendelenburg, Patrick Y Müller, László Urbán. With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing. Print version record. Drug development. Drugs Design. Drugs Side effects. Drug interactions. Drug development. Drugs Design. Medicine. MEDICAL Pharmacology. bisacsh Drug development. fast (OCoLC)fst00898670 Drug interactions. fast (OCoLC)fst00898681 Drugs Design. fast (OCoLC)fst00898790 Drugs Side effects. fast (OCoLC)fst00898912 Electronic books. Urbán, László. Patel, Vinod F. Vaz, Roy J. Print version: Urban, Laszlo. Antitargets and Drug Safety. Hoboken : Wiley, ©2015 9783527335114 Methods and principles in medicinal chemistry ; v. 66. http://onlinelibrary.wiley.com/book/10.1002/9783527673643 Wiley Online Library ddc BK 207926 207926