05549cam a2200613Ii 4500 ocn900723990 OCoLC 20171025124239.0 m o d cr cnu|||unuuu 150126s2015 gw ob 001 0 eng d 9783527684410 electronic bk. 3527684417 electronic bk. 9783527684403 3527684409 9783527337941 3527337946 9781322776422 MyiLibrary 1322776423 MyiLibrary DEBSZ 43187512X DEBBG BV043397474 (OCoLC)900723990 (OCoLC)902417600 N$T eng rda pn N$T IDEBK N$T E7B YDXCP COO RECBK OCLCF CUS EBLCP DEBSZ UIU DEBBG CCO MAIN QD415 (S SCI 013040 bisacsh 547/.7 23 Bioactive Natural Products : Chemistry and Biology / edited by Goutam Brahmachari. [electronic resource] Weinheim, Germany : Wiley-VCH, 2015. 1 online resource (xxxiv, 507 pages) text txt rdacontent computer c rdamedia online resource cr rdacarrier Includes bibliographical references and index. Bioactive Natural Products; Contents; Foreword; Preface; About the Editor; List of Contributors; Chapter 1 An Overview; 1.1 Introduction; 1.2 An Overview of the Book; 1.2.1 Chapter 2; 1.2.2 Chapter 3; 1.2.3 Chapter 4; 1.2.4 Chapter 5; 1.2.5 Chapter 6; 1.2.6 Chapter 7; 1.2.7 Chapter 8; 1.2.8 Chapter 9; 1.2.9 Chapter 10; 1.2.10 Chapter 11; 1.2.11 Chapter 12; 1.2.12 Chapter 13; 1.2.13 Chapter 14; 1.2.14 Chapter 15; 1.2.15 Chapter 16; 1.2.16 Chapter 17; 1.3 Concluding Remarks; Chapter 2 Use of Chemical Genomics to Investigate the Mechanism of Action for Inhibitory Bioactive Natural Compounds. 2.1 Introduction: Antibiotic Resistance and the Use of Natural Products as a Source for Novel Antimicrobials2.2 Chemical Genetics and Genomics; 2.3 Development of GDA Technology; 2.3.1 The Use of Gene Deletion Arrays (GDAs) to Investigate MOA; 2.3.2 Chemical Genetic Interactions; 2.3.3 Quantifying Genetic and Chemical Genetic Interactions; 2.3.4 Data Analysis; 2.3.5 Platforms for Chemical Genomic GDA Studies; 2.3.6 Why Screen Natural Products in GDAs?; 2.3.7 Successful Applications of GDA Technology; 2.4 Concluding Remarks; Abbreviations; References. 880-01 Chapter 4 Immunosuppressants: Remarkable Microbial Products4.1 Introduction; 4.2 Discovery; 4.3 Mode of Action; 4.4 Biosynthesis; 4.4.1 Acetate, Propionate, Butyrate, Methionine, and Valine as Precursors of the Macrolide Rings of Sirolimus, Ascomycin, and Tacrolimus; 4.4.2 Pipecolate Moiety of the Macrolide Ring of Sirolimus, Ascomycin, and Tacrolimus; 4.4.3 The Final Step in Biosynthesis of Ascomycins and Tacrolimus; 4.4.4 Formation of the Substituted Cyclohexyl Moiety of Sirolimus, Tacrolimus, and Ascomycins; 4.4.5 Biosynthesis of Cyclosporin; 4.5 Genetics and Strain Improvement. 4.6 Fermentation and Nutritional Studies4.7 Other Activities of Immunosuppressants; 4.8 Concluding Remarks; Acknowledgments; References; Chapter 5 Activators and Inhibitors of ADAM-10 for Management of Cancer and Alzheimer's Disease; 5.1 Introduction to ADAM Family of Enzymes; 5.2 ADAM-10 Structure and Physiological Roles; 5.3 Pathological Significance; 5.3.1 Modulating ADAM Activity in Neurodegeneration; 5.3.2 ADAM-10 in Cancer Pathology; 5.4 ADAM-10 as Potential Drug Target; 5.5 Synthetic Inhibitors of ADAM-10; 5.6 Natural Products as Activators and Inhibitors for ADAM-10. Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural productsFeatures chemi. Vendor-supplied metadata. Natural products. Biochemistry. SCIENCE / Chemistry / Organic bisacsh Biochemistry. fast (OCoLC)fst00831961 Natural products. fast (OCoLC)fst01034390 Electronic books. Electronic books. Brahmachari, Goutam, editor. Print version: Brahmachari, Goutam. Bioactive Natural Products : Chemistry and Biology. Hoboken : Wiley, ©2015 9783527337941 http://onlinelibrary.wiley.com/book/10.1002/9783527684403 Wiley Online Library 505-01/(S Chapter 3 High-Throughput Drug Screening Based on Cancer Signaling in Natural Product Screening3.1 Introduction; 3.2 Cancer Signaling Pathways with Their Own Drug Screening Assays in HTS; 3.2.1 β-Galactosidase Enzyme Complementation Assays for EGFR Signaling Drug Screening; 3.2.2 Fluorescence Superquenching Assays for PI3Ks Signaling Drug Screening; 3.2.3 TOP Flash Reporter Gene Assays for Wnt Signaling Drug Screening; 3.2.4 Luciferase Reporter Gene Assays for STATs Signaling Drug Screening; 3.3 Concluding Remarks; Abbreviations; References. ddc BK 207853 207853